other medication for rheumatoid arthritis

Question 1

Sulfasalazine two products

Answer 1

cleaved to sulfapyridine and 5- aminosalicylic acid by intestinal bacteria
- sulfapyridine is an sulphonamide antibiotic
- 5- aminosalicylic acid is an anti-inflammatory

Question 2

Sulfasalazine mechanism of action

Answer 2

inhibits the activation of nuclear factor of kB (NF-KB) and subsequently reduces production of TNF-a, IL-6 and IL-1 can also be used to treat IBS

Question 3

name three derivatives of sulfasalazine that are aminosalicylates

Answer 3

mesalazine ( 5-aminosalicyclic acid), balsalazide (“), olsalazine only used used in IBS not rheumatoid arthritis

Question 4

Hydroxychloroquine

Answer 4

was used an antimalarial, malaria is an intracellular pathogen and hydroxychloroquine has high intracellular concentrations.
acts as an immunosuppressant and inhibits intracellular toll like receptors 7 and 9 inhhibits activation of PRRr. and co stimulation of t cells