Other drugs

Question 1

Name a Non-selective Muscarinic Ach Receptor Antagonist

Answer 1

Atropine

Question 2

What is the mechanism of Atropine

Answer 2

Competitive antagonist – Increases HR in normal subjects at all but low doses – no effect. No effect on the response to exercise. Always use >600mg.
First line in management of severe bradycardia

Question 3

What conditions is Atropine used for

Answer 3

Severe bradycardia

Anticholinesterase poisoning – reduces excessive parasympathetic activity e.g after MI when vagal tone ↑

Question 4

What are the side effects of Atropine

Answer 4

<300mg can transiently reduce HR. Use no less than 600mg