Anti- Thrombotic Drugs Flashcards
Name 3 types of Anti-Thrombotic drugs
Anti-platelets, Anti-coagulants, Fibrinolytics
Name 4 Anti-platelet drugs
Aspirin
Clopidogrel
Ticagrelor
Prasugrel
Name 4 Anti-coagulant drugs
Warfarin – oral use only
Heparin
Rivaroxaban
Dabigatran
Name 3 fibrinolytic drugs
Streptokinase
Alteplase
Duteplase
What is the mechanism of Anti-platelet drugs
They all prevent new thrombosis
irreversibly block cycloxygenase (COX) in platelets, preventing TXA2 synthesis, but also COX in endothelial cells inhibiting production of antithrombotic prostaglandin I2 (PGI2)
What is the mechanism of Anticoagulant drugs
Prevents new thrombosis, Warfarin blocks clotting factors 2, 7, 9, 10
Heparin must bind to both AT III and IIa to inhibit IIa
Heparin need bind only to AT III to inhibit Xa
Rivaroxaban is a factor Xa inhibitor
Dabigatran is a thrombin factor IIa inhibitor. Xa converts II→IIa
What is the mechanism of fibrinolytic drugs
Dissolve formed clots
Streptokinase, alteplase and duteplase activate plasminogen which turns into plasmin and breaks up fibrin into fragments
What are Anti-platelets used for
Angina
Acute MI
CVA/TIA
What are Anticoagulants used for
DVT
PE
NSTEMI
Atrial Fibrillation
What are the side effects of Anti-platelets
Haemorrhage elsewhere
Peptic ulcer → haemorrhage
Aspirin sensitivity→Asthma
What are the side effects of Anticoagulants
Haemorrhage
What are the side effects of Fibrinolytics
Trauma
Bleeding tendencies
Increases the risk of haemorrhagic stroke
