Other Causes of Acute Tubulointerstitial Disease Leading to AKI Flashcards
1
Q
Drugs associated with the development of an allergic response in the kidneys are characterized by:
A
I-E
- inflammatory infiltrate and
- peripheral and urinary eosinophilia
2
Q
Give some drugs that are associated with the development of an allergic response in the kidneys
A
Proton pump inhibitors and NSAIDS
- associated with acute tubulointerstitial nephritis
3
Q
What are other causes of tubulointerstitial disease leading to AKI?
A
DSM/N
- Drugs (PPI and NSAIDs)
- Severe infections
- Infiltrative malignant or nonmalignant (ex. sarcoidosis) diseases
4
Q
How does glomerulonephritis lead to AKI?
A
Diseases involving the glomerular podocytes, mesangial and endothelial cells can lead to AKI by compromising the (1) filtration barrier and (2) blood flow within the renal circulation.
