Chemotherapeutic Agents

Question 1

Chemotherapeutic agents that cause AKI:

Answer 1

Cisplatin and carbopplatin- proximal tubular cell necrosis and apoptosis

Ifosfamide- hemorrhagic cystitis and tubular toxicity

Bevacizumab- antiangiogenesis agent

Mitomycin c and gemcitabine- antineoplastic agents

Question 2

mechanism of AKI in cisplatin and carboplatin:

Answer 2

are accumulated by proximal tubular cells and cause necrosis and apoptosis.

Question 3

Ifosfomide nephrotoxicity manifests as:

Answer 3

Type II renal tubular acidosis (Fanconi’s Syndrome)

Question 4

mechanism of AKI in Ifosfamide:

Answer 4

may cause hemorrhagic cystitis and tubular toxicity, manifested as type II renal tubular acidosis (Fanconi’s syndrome), polyuria,
hypokalemia, and a modest decline in GFR

Question 5

mechanism of AKI in Ifosfamide:

Answer 5

may cause hemorrhagic cystitis and tubular toxicity, manifested as type II renal tubular acidosis (Fanconi’s syndrome), polyuria,
hypokalemia, and a modest decline in GFR

Question 6

mechanism of AKI in Ifosfamide:

Answer 6

may cause hemorrhagic cystitis and tubular toxicity, manifested as type II renal tubular acidosis (Fanconi’s syndrome), polyuria,
hypokalemia, and a modest decline in GFR

Question 7

mechanism of AKI in Ifosfamide:

Answer 7

may cause hemorrhagic cystitis and tubular toxicity, manifested as type II renal tubular acidosis (Fanconi’s syndrome), polyuria,
hypokalemia, and a modest decline in GFR