Other

Question 1

Relative potency steroids compared to hydrocortisone (cortisol)

Answer 1

prednison 4
methylpred 5
fludrocortisone 10
dexamethasone 25 (no mineralocorticoid action)

Question 2

metformin PK

Answer 2

A: PO
D: T1/2 11h not protein bound
M: not
E: renal unchanged - accumulated in CRF

Question 3

Octreotide

Answer 3

somatostatin analogue
T1/2 1.5h
reduces variceal pressure in bleed
tx sulfonylurea OD, hormone secreting tumors, diarrhoea
se - GI, deranged BSL, sinus brady

Question 4

Sulfonamides structural analogues of

Answer 4

para amino benzoic acid

Question 5

CYP2D6 inhibitors

Answer 5

amiodarone
fluoxetine

Question 6

Desmopression

Answer 6

D2 agonist for DI
also inc VWF and VIII

Question 7

Bisphosphonate SEs

Answer 7

esophagitis, osteonecrosis of the jaw, and pathological femoral stress fractures

Work by inhibiting osteoclasts

Question 8

digoxin half life

Answer 8

39 hours

Question 9

Diazepam half life

Answer 9

43 hours

Question 10

Lidocain half life

Answer 10

1-2hours
increased in liver failure

Question 11

Oral bioavailability digoxin

Answer 11

70%

Question 12

Enzyme inhibitors

Answer 12

SICKFACES.COM + Grapefruit

Sodium valproate; Isoniazid (noting current text states inducer); Cimetidine; Ketoconazole; Fluconazole; Alcohol (binge); Amiodarone; Chloramphenicol; Erythromycin; Sulphonamides; Ciproflox; Omeprazole; Metronidazole.

Quinine

Question 13

Enzyme inducers

Answer 13

CRAP GPs

Carbamazepine; Rifampicin; Alcohol (chronic); Phenytoin; Griseofulvin; Phenobarbitone; Sulphonylureas

Question 14

Atropine half life

Answer 14

4.3 hours

Question 15

Phase 1 reaction lidocain

Answer 15

Hydrolysis

Question 16

Phase 1 reaction ethanol

Answer 16

P450 oxidation

Question 17

Phase 1 reaction morphine

Answer 17

Oxidative dealkylation

Question 18

Pge1

Answer 18

Vasodilation

Question 19

Pge2

Answer 19

Smooth muscle contraction
Fever
Bronchoconstriction

Question 20

Pgf2alpha

Answer 20

Uterine contraction

Question 21

Pgi2

Answer 21

Inhibition plt aggregation
Vasodilation
Embryo implantation

Question 22

Verapamil bioavailability

Answer 22

10-35% due to first pass

Question 23

Cimetidine half life

Answer 23

2 hours

Question 24

Cholinomimetic for treatment MG

Answer 24

Neostigmine

Question 25

Tetanus vaccines

Answer 25

Toxoid - artificial active
Antitoxin - artificial passive
Natural from mother
Passive when antibody given

Question 26

Antiemetic vitamin in pregnancy

Answer 26

B6

Question 27

Renal dose dopamine

Answer 27

1-20mcg/kg/m

Question 28

Drugs contraindicates in porphyria

Answer 28

Amiodarone
Barbiturates
D2 antagonists