Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Part 1 Pharmacology > Other > Flashcards

Other Flashcards

1
Q

Relative potency steroids compared to hydrocortisone (cortisol)

A

prednison 4
methylpred 5
fludrocortisone 10
dexamethasone 25 (no mineralocorticoid action)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

metformin PK

A

A: PO
D: T1/2 11h not protein bound
M: not
E: renal unchanged - accumulated in CRF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Octreotide

A

somatostatin analogue
T1/2 1.5h
reduces variceal pressure in bleed
tx sulfonylurea OD, hormone secreting tumors, diarrhoea
se - GI, deranged BSL, sinus brady

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Sulfonamides structural analogues of

A

para amino benzoic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CYP2D6 inhibitors

A

amiodarone
fluoxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Desmopression

A

D2 agonist for DI
also inc VWF and VIII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Bisphosphonate SEs

A

esophagitis, osteonecrosis of the jaw, and pathological femoral stress fractures

Work by inhibiting osteoclasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

digoxin half life

A

39 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Diazepam half life

A

43 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lidocain half life

A

1-2hours
increased in liver failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Oral bioavailability digoxin

A

70%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Enzyme inhibitors

A

SICKFACES.COM + Grapefruit

Sodium valproate; Isoniazid (noting current text states inducer); Cimetidine; Ketoconazole; Fluconazole; Alcohol (binge); Amiodarone; Chloramphenicol; Erythromycin; Sulphonamides; Ciproflox; Omeprazole; Metronidazole.

Quinine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Enzyme inducers

A

CRAP GPs

Carbamazepine; Rifampicin; Alcohol (chronic); Phenytoin; Griseofulvin; Phenobarbitone; Sulphonylureas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Atropine half life

A

4.3 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Phase 1 reaction lidocain

A

Hydrolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Phase 1 reaction ethanol

A

P450 oxidation

17
Q

Phase 1 reaction morphine

A

Oxidative dealkylation

18
Q

Pge1

A

Vasodilation

19
Q

Pge2

A

Smooth muscle contraction
Fever
Bronchoconstriction

20
Q

Pgf2alpha

A

Uterine contraction

21
Q

Pgi2

A

Inhibition plt aggregation
Vasodilation
Embryo implantation

22
Q

Verapamil bioavailability

A

10-35% due to first pass

23
Q

Cimetidine half life

A

2 hours

24
Q

Cholinomimetic for treatment MG

A

Neostigmine

25
Q

Tetanus vaccines

A

Toxoid - artificial active
Antitoxin - artificial passive
Natural from mother
Passive when antibody given

26
Q

Antiemetic vitamin in pregnancy

A

B6

27
Q

Renal dose dopamine

A

1-20mcg/kg/m

28
Q

Drugs contraindicates in porphyria

A

Amiodarone
Barbiturates
D2 antagonists

Part 1 Pharmacology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions