osteoporosis

Question 1

When to repeat bone turnover markers after therapy is started?

Answer 1

Repeat after 3-6 months of your life treatment

Question 2

What are the biochemical markers of bone resorption? (2)

Answer 2

1. Serum C-telopeptide (CTX)
2. Urinary n-telopeptide (ntx)

Question 3

What are the biochemical markers of bone formation? (3)

Answer 3

1.serum amino-terminal propeptide of type 1 procollagen
2.bone-specific alkaline phosphatase (BALP)
3. Osteocalcin (OC)

Question 4

What percentage of change in CTX indicates an success in anti-reabsorptive treatment?

Answer 4

40% reduction in CTX (double check that is correct)

Question 5

Can someone ever get rid of the diagnosis of osteoporosis?

Answer 5

No-successful treatment can increase BMD, reduce fracture
risk, and improve T-score to the low bone mass or even the
normal range. However, in a person with a history of osteo-
porosis, a T-score in the osteopenic or normal range does not
change their diagnosis. The patient still has osteoporosis.
BMD may be improved, and fracture risk reduced; however,
microarchitectural deterioration remains, as do disease pro-
cesses responsible for that deterioration.

Question 6

After how many years of bisphosphonate therapy should you consider a drug holiday?

Answer 6

after 3 years of IV bisphosphonates and after 5 years of oral bisphosphonates

Question 7

when is the right time to check calcium on forteo?

Answer 7

obtain calcium right before next dose is due (forteo can cause calcium to be high)

Question 8

generic drug name for forteo

Answer 8

Teriparatide

Question 9

generic drug name for Tymlos

Answer 9

abaloparatide (no available on the market yet)