Osteo Flashcards
What joints are involved in osteoarthritis?
Distal interphalangeal joint, hips and knees
What is the difference between a Herberden and Bouchard node?
Herberden- upper joint in hand
Bouchard- lower joint in hand
What is the presentation of inflammation in osteoarthritis?
Absent or mild
T/F: Osteoarthritis therapy can repair the integrity of the joint affected
False: therapy is for pain and discomfort relief
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What are three topical therapy options of Osteoarthritis?
Menthol, Camphor, Oil of Wintergreen
What topical therapy depletes substance P? What is its wait time for results? Side effects?
Capsaicin Cream (Zostrix)
Wait 2-4 weeks for results
SE: Burning, stinging, and redness
What OTC topical therapy for osteoarthritis uses local inhibition of COX-2 enzymes? Its recommendation? Side effects?
Diclofenac Gel 1%- Voltaren Gel
Not recommended in combo with systemic NSAID
SE: pruritus, burning, pain and rash
What prescribed topical therapy for osteoarthritis is used for the knee only? Side effect?
Diclofenac Topical Solution- Pennsaid
SE: Local reaction
What is acetaminophens (Tylenol) method of action within the body? Its max dose and trial time?
Inhibits synthesis of prostaglandins
Max dose 2-4g per day
2-4 week trial on scheduled dose
Where is acetaminophen contraindicated?
Patients at risk for hepatotoxicity (liver disease, heavy alcohol intake)
What is some of the greatest contraindications for NSAID therapy?
Anticoagulants/Antiplatelet and glucocorticoids
How are NSAIDs monitored in patients?
Blood pressure, swelling, kidney function (SCr) every 3 mon, Hemoglobin (Hgb/Hct) every 6-12 mon, signs of dehydration
What COX-2 inhibitor can be used to lower incidence of GI bleeding?
Celebrex
