Osmoregulation Flashcards

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1
Q

What is negative feedback?

A

mechanisms to restore any deviations from normal in a system back to its original state

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2
Q

Why is osmoregulation important?

A

-HYPERTONIC: too much water leaves cells, crenation, chemical reactions etc, cant occur

  • HYPOTONIC: water moves into cells, so cells burst, lysis.
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3
Q

What is hypertonic?

A

blood has too low water potential (less water more ions)

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4
Q

What is hypotonic?

A

blood has too high water potential (more water less ions)

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5
Q

What might cause blood to be hypertonic?

A
  • lots of ions in food
  • not enough water
  • sweating
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6
Q

What might cause blood to be hypotonic?

A
  • too much water
  • not enough ions
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7
Q

What detects change in water potential?

A

osmoreceptors in the hypothalamus

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8
Q

Where is ADH produced?

A

osmoreceptors in the hypothalamus

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9
Q

What stimulates MORE ADH to be produced?

A

water leaves osmoreceptor cells, stimulating ADH to be produced

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10
Q

Where is ADH released?

A

posterior pituitary gland

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11
Q

What effect does ADH have?

A
  • increases the permeability of the walls of the distal convoluted tubule and collecting ducts
  • so more water is reabsorbed
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12
Q

What happens when ADH reaches the kidneys?

A
  • ADH binds to complementary receptors on the cell membranes of epithelial cells of the collecting duct
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13
Q

What happens when ADH binds to receptors?

A

activates phosphorylase enzyme in the cells

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14
Q

What does phosphorylase cause to happen?

A
  • vesicles containing aquaporins
  • fuse to cell membranes, integrating more aquaporins into the membrane
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15
Q

What are aquaporins?

A

channel proteins that allow water to pass through

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16
Q

What is the effect of ADH on the collecting ducts?

A
  • more channel proteins
  • membrane is more permeable to water
  • water moves into blood by osmosis
17
Q

How does the loop of Henle reabsorb water from glomerular filtrate? (5 points)

A
  • ascending limb, Na+ actively transported out
  • ascending limb impermeable to water
  • Na+ diffuse in to descending limb
  • water moves out of descending limb to the medulla, which has a lower water potential, by osmosis
  • longer loop = lower WP in medulla
18
Q

What causes osmoreceptors to release ADH?

A
  • low water potential in the blood
  • water moves out by osmosis
  • cell shrivels, ADH secreted
19
Q

How does ADH allow water to enter the blood?

A
  • ADH binding causes vesicles containing aquaporins to fuse to the membrane
  • water can move into epithelial cells by osmosis
  • water then moves into the capillary