OSCE Stop Common S/E Flashcards
List 4 common S/E for anti-cholinergic/muscarinic?
dilated pupils + blurred vision
dry mouth
constipation
urinary retention
List 2 common S/E for anti-histaminergic?
weight gain
sedation
Which drugs commonly cause anti-cholinergic/muscarinic S/E?
TCAs Antihistamines Hyoscine Atropine anti-psychotics PPI
Which drugs commonly cause anti-histaminergic S/E?
TCAs
anti-psychotics
anti-histamines.
List 3 common S/E of alpha-adrenergic block?
Postural hypotension
sexual dysfunction
nasal congestion
List 3 common anti-dopaminergic S/E?
EPS
hyperprolactinaemia
Neuroleptic malignant syndrome
Which 3 drugs commonly cause alpha-adrenergic S/E?
TCA
Anti-psychotics
alpha-blockers - doxazosin, tamsulosin.
Which 2 drugs cause anti-dopaminergic S/E?
Metoclopramide
anti-psychotics
What are the single most common side effect of the 4 TB drugs?
Rifampicin - red/orange tears/urine.
Isoniazid - neuropathy
Pyrazinamide - hepatitis
Ethambutol - optic neuritis.
RICE
What is the most important S/E of lamotrigine and how is this mitigated?
rash - SJS risk
very slow dose titration
Common S/E of SSRIs?
nausea, low libido, withdrawal, insomnia, GI upset initially.
Common S/E of TCA?
anti-muscarinic mostly.
Common S/E of MAOI
HHH
Hypertension
Hepatocellular jaundice
Hyperthermia
Common S/E of phenytoin?
acne
course face
gum hypertrohpy
hirsutism
Which 2 anti-epileptics can cause hair thinning?
carbamazepine
sodium valproate
Which 2 anti-epileptics can cause rash and SJS syndrome?
Lamotrigine
Carbamazepine
What are most common S/E of ACE-i?
dry cough
postural hypotension
renal failure in RAS - re-check U&E’s
angioedema
What are most common S/E of Ca blockers?
ankle oedema
headache
flushing
dizziness
What are most common S/E of beta-blockers?
diabetes impotence bradycardia low exercise tolerance/fatigue cold extremities
What are most common S/E of diuretics?
hypokalaemia (except K-sparing)
dehydration
hypotension
hypomagnesemia
What are most common S/E of sulfasalazine?
discolour urine/tears (contacts).
myelosuppression
hepatitis
rash (SJS)
What are most common S/E of MTX
blood - sore throat, mucositis.
liver - dark urine, pale stool, abdominal pain.
lung - SOB, chest pain
What are most common S/E of metformin?
weight loss
lactic acidosis
metallic taste
GI upset
What are most common S/E of sulphonylureas?
hypo
weight gain
What are most common S/E of thiazolidinediones
fluid retention
hepatotoxic
bone fractures
What are most common S/E of contraception?
weight gain
acne
mood changes
headaches
What are most common S/E of clozapine?
agranulocytosis
monitor FBC and leukocytes regularly.
Most common S/E for chlorpromazine?
cholestatic jaundice
Most common S/E for haloperidol?
QT porlongation
hypotension
What are the symptoms of lithium toxicity?
tremor
ataxia
coma
convulsions
hypotension
Most common S/E for lithium?
nausea & diarrhoea
hypothyroidism
diabetes insipidus
Most common S/E for steroids?
diabetes Cushings osteoporosis hypokalaemia infection
Most common S/E for L-dopa?
nausea red urine postural hypotension on/off effects dyskinesias
Most common S/E for PPI?
tinnitus
nausea/diarrhoea/constipation
hypomagnesaemia
Most common S/E for amiodarone?
Lung - fibrosis Thyroid - thyroiditis Skin - gray, photosensitivity, Liver - hepatitis metallic taste
Most common S/E for digoxin?
CNS - yellow/orange halo vision
GI - n+v, diarrhoea.
Cardiac - arrhythmias
Which drugs can cause HYPERnatraemia?
sodium containing antibiotics, bicarbonate and fluids.
Which drugs can cause HYPOnatraemia?
antidepressants diuretics lithium chlorpromazine carbamazepine
Which drugs can cause HYPERkalaemia?
K-sparing diuretics
ACE-I
NSAIDs
trimethoprim
Which drugs can cause HYPOnatraemia?
salbutamol
insulin
diuretics
caffeine
Which drugs can cause HYPERcalcaemia?
thiazide diuretics
Which drugs can cause HYPOcalcaemia?
Loop diuretics
bisphosphonates
phenytoin
Which 4 C drugs can cause agranulocytosis?
Carbamazepine
Clozapine
Colchicine
Carbimazole
Which 4C drugs can cause C.diff?
Cephalosporins
Co-amox
Clindamycin
Ciprofloxacin
