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Revision for GPhC Exam > OSCE Stop - Common drug interactions > Flashcards

OSCE Stop - Common drug interactions Flashcards

1
Q

What are the enzyme INDUCER drugs?

A

CRAPS

Carbamazepine
Rifampicin 
bArbiturates
Phenytoin 
St Johns Wort
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2
Q

What is the nemonic for enzyme INHIBITOR drugs?

A

SICKFACES.COM

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3
Q

What are the enzyme INHIBITOR drugs?

A 
Sodium valproate 
Isoniazid 
Cimetidine
Ketoconazole
Fluconazole
Alcohol + Grapfruit juice 
Ciprofloxacin 
Erythromycin
Sulfonamides 
.
Chloramphenicol 
Omeprazole 
Metronidazole
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4
Q

What are the 9 drugs which are narrow TI and require monitoring?

A 
Gent
Warfarin
Lithium 
Digoxin 
Theophylline
MTX
Phenytoin 
Insulin
Ciclosporin
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5
Q

What is the nemonic for drugs with narrow TI which require monitoring?

A 
Guys
With 
Large 
Dongles
Totally 
Make 
Perfect 
Internet 
Connections
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6
Q

Describe the interaction between metformin + cimetidine?

A

cimetidine increased exposure to metformin - increased risk lactic acidosis.

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7
Q

Describe the interaction between gent + loop diuretics?

A

both impact renal function - increased risk renal failure.

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8
Q

Describe the interaction between ACE-I + K-sparing diuretics?

A

Hyperkalaemia - both preserve K.

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9
Q

Describe the interaction between ACE-I + metformin?

A

ACE-I reduce renal clearance of metformin = increased exposure - enhance hypoglycaemic effect.

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10
Q

Describe the interaction between statin + macrolides?

A

Macrolides inhibit statin metabolism = inc exposure = inc risk myopathy.

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11
Q

Describe the interaction between statin + amiodarone?

A

Amiodarone inhibits statin metabolism = inc exposure = inc risk rhabdo.

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12
Q

Describe the interaction between thiazide + PPI?

A

hyponatraemia

(PPI also = hypomagnesaemia).

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13
Q

Describe the interaction between thiazide and lithium?

A

thiazide prevents lithium excretion = inc toxicity.

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Revision for GPhC Exam (11 decks)

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