Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Ortho > Orthopedic pharm > Flashcards

Orthopedic pharm Flashcards

1
Q

MOA of NSAIDs

A

block PG synthesis via inhibiting COX enzymes at the site of injury, in the periphery and in the brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what does acetaminophen not have antiinflammatory properties

A

inactivated by peroxides generated by leukocytes in inflamed tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is motrin/advil

A

ibuprofen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is aleven

A

naproxen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is indocin

A

indomethacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is toradol

A

ketorolac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

MOA: inhibit AA activation of platelets and decreases platelet function and/or a decrease in PG METABOLITES

A

acetylsalicylic acid/asprin (bayer)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

SE of aspirin

A

tinnitus
anemia
gastritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

clinical use for ibuprofen

A

mild to moderate pain or dysmenorrhea

inflammatory disorders - OA and RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

clinical use of naproxen (aleve)

A

inflammatory disorders - gouty arthritis, OA, RA, ankylosing spondylitis, patent ductus arteriosus in premies

reserved for pts not responding to less toxic drugs

(same as indomethacin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

clinical use of indomethacin (indocin)

A

inflammatory disorders - gouty arthritis, OA, RA, ankylosing spondylitis, patent ductus arteriosus in premies

reserved for pts not responding to less toxic drugs

(same as naproxen)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

drug for short term management of pain

available as IM injection

prolongs bleeding time; use must be limited to 5 days or less

A

Ketorolac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are the selective COX-2 inhibitor NSAIDs

A

celecoxib

meloxicam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

clinical use of celecoxib

A

OA and RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what are the strong opiate agonists

A

fetanyl

mepridine

morphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are the moderate opiate agonists

A

codeine - mild-moderate pain

hydrocodone - often combined with acetaminophen or NSAID

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Tramadol is a 1 (class of drug) and is a synthetic analgesic. Like morphine, it binds to receptors in the 2 that transmit pain sensation. It is not an NSAID and does not increase the risk of 3 and 4 that can occur with NSAIDs

A
  1. non-narcotic
  2. brain
  3. stomach ulceration
  4. internal bleeding
18
Q

inject medication around a SPECIFIC nerve to block sensory and motor fibers distal to the block

A

regional nerve block

19
Q

bupivacaine is what

A

local anesthetic - inhibits the ionic fluxes; blocks fast voltage gated Na+ channels

20
Q

what can lidoderm patch treat

A

post-herpetic neuralgia

maybe low back pain

21
Q

PO route muscle relaxers

A

metaxolone

carisoprodol

cyclobenzaprine

PO, IM, IV = benzos –> diazepam and midazolam

22
Q

Tx for gout that inhibits uric acid synthesis

A

allopurinol

23
Q

Tx for gout that increases uric acid excretion with uricosuric agents (and blocks renal tubular reabsorption of uric acid)

A

probenecid

sulfinpyrazone

24
Q

what is the most widely used agent for decreasing the frequency of ACUTE gouty attacks

A

colchicine

25
Q

Tx for gout that inhibits leukocyte entry into the affected joint

A

colchicine

26
Q

drugs that help reduce inflammation and slow disease progression

A

DMARDs

27
Q

in RA or PsA, ____ can cause your immune system to attack healthy tissues in your body and cause inflammation and damge

A

TNFalpha

28
Q

Most serious side effect of TNF blockers

A

increased frequency of infections, especially TB –> TB skin text required before starting TNF therapies

29
Q

3 TNF blocker drugs

A

infliximab

etanercept

adalimumab

30
Q

what does MTX treat

A

RA

PsA at small doses

31
Q

when taking MTX what is also necessary to take?

A

vitamin folic acid

32
Q

what can azulfidine (sulfasalzine) used to treat

A
  • arthritis

- intestinal lesions in IBD

33
Q

drug that may help to keep cartilage healthy by absorbing fluid into the CT

A

chondroitin

34
Q

what can glucosamine be used to treat - what is its beneft?

A

OA - particularly of the knee

benefit in synovial fluid - strengthens cartilage and aids in glycosaminoglycan synthesis

35
Q

what does hyaluronic acid treat and what does it do? (orthovisc, synvisc, supartz)

A

OA

supplements knee fluid to relieve pain and improve the knee joint’s natural shock absorbing abilities

restore viscoelasticity of synovial fluid, augment flow of fluid, normalize synthesis, inhibit degradation of endogenous hyaluronic acid and relieve joint pain

36
Q

corticosteroids use

A

pain relief of arthritis or bursitis

37
Q

why would you not use corticosteroids in achilles tendonitis

A

risk of tendon rupture

38
Q

what might steroid use cuase in diabetic patients

A

hyperglycemia

39
Q

actions of glucocorticoids

A

anti-inflammatory

immunosuppressent

40
Q

short acting injectable corticosteroids

A

cortisone

hydrocortisone

41
Q

intermediate acting injectable corticosteroids

A

prednisolone tebutate

triamcinolone and methylprednisolone

42
Q

long acting injectable corticosteroids

A

dexamethasone

beamethasone

Ortho (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions