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Micro III > Orthomyxoviridae > Flashcards

Orthomyxoviridae Flashcards

1
Q

Main genera of the Orthomyxoviridae

A

Influenza A-D, Isavirus, Thogotovirus, Quaranjavirus

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2
Q

Orthomyxoviridae envelope

A

Yes

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3
Q

Orthomyxoviridae nucleocapsid

A

Helical

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4
Q

Orthromyxoviridae morphology

A

Usually spherical or pleomorphic, long filamentous forms occur

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5
Q

Orthomyxoviridae genome

A

RNA, segmented

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6
Q

Orthomyxoviridae replication

A

In the nuclei

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7
Q

Important virulence factors of Orthomyxoviridae

A

Hemagglutinin and neuraminidase

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8
Q

Hemagglutinin

A

Glycoprotein that allows Orthomyxoviridae to attach cells.
Has two chains.
Causes multiple RBC to clump together

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9
Q

Hemagglutinin chain

A

1st chain binds to sugar molecules on the cell surface

2nd chain attacks the cell

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10
Q

Neuraminidase

A

Allows virus to escape from cells by breaking them

Liquefacts mucus-> transport on the mucociliary clearance in airways from bottom to up

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11
Q

Influenzavirus A

A

respiratory infections on wide host range (aquatic organisms-> mammals)

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12
Q

Influenzavirus B

A

infects humans and seals

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13
Q

Influenzavirus C

A

Mild respiratory symptoms in humans and swine

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14
Q

Infuenzavirus D

A

Infects swine and cattle

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15
Q

Thogotovirus

A

ticks spread to humans and livestock

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16
Q

Quaranjavirus

A

Ticks, birds, sometimes humans

17
Q

Isavirus

A

Infectious salmon anemia

18
Q

Ag shift in influenza viruses

A

in a and b every 2-3 years, ensures presence of immunologically susceptible people

19
Q

Transmission of influenzaviruses

A

aerosol

20
Q

transmission of isavirus

A

water

21
Q

Prevention of influenzaviruses

A

vaccines

22
Q

Isavirus clinical signs

A

pale gills, bloated abdomen, bleeding, swimming closer to the surface

23
Q

Diagnosis of Orthomyxoviridae

A 
cell culture or inside egg
elisa
pcr
immunofluorescence
haemagglutination tet

Micro III (5 decks)

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