Flaviviridae Flashcards
Flaviviridae envelope
yes
Flaviviridae nucleocapsid
icosahedral
Flaviviridae in environment
labile
Flaviviridae replication
in cytoplsdm
Flaviviridae gets out of cell by
exoxytosis
Flaviviridae important genera
Flavivirus (zoonotic) and Pestivirus
Flavivirus includes
West nile virus
West nile virus transmission
by arthropod vector(mosquito and tick)
blood/meat from carcasses
unpasteurised milk
West nile virus causes
encephalitis of horses, birds, and humans
west nile virus clinical signs
encephalomyelitis with clinical signs in horses: anorexy depression weakness ataxia even coma and death in 30% of cases
birds:asymptomatic
West nile virus samples:
birds: any affected tisue
horses: brain, spinal cord, blood
West nile virus diagnosis
pcr, elisa, immunofluorescence, plaqcue reduction neutralisation test
important pestivirus
bovine viral diarhhea virus I ja II, border disease virus and classical swine fever virus
pestivirus virulence factors
3 envelope glycoproteins Erns (soluble ribonuclease), E and E2(which neutralises ab)
bovine viral diarrhea transmission
oronasal and transplacental
bovine viral diarrhea virus causes
immunosupression in calves
enteric and respiratory diseases
abortions and still births (if infection during early pregnancy, persistent infection may occur unlike if infection in late pregnancy, if infection in mid-pregnany, congenital defects may occur)
bovine viral diarrhea clinical signs in adults
fever, letharhy, anorexia, nasal and ocular discharges, oral lesions, diarhhea,
bovine viral diarhhea samples
blood, serum, spleen, lymph nodes, gi tract lesions, milk
bovine viral diarrhea diagnosis
ab’s from blood and milk, pcr and elisa
