Bornaviridae

Question 1

Bornaviridae shape

Answer 1

Spherical

Question 2

Bornaviridae genome

Answer 2

RNA

Question 3

Bornaviridae envelope

Answer 3

yes

Question 4

Bornaviridae replication

Answer 4

inside neural cell nucclei

Question 5

Bornaviridae species

Answer 5

Bornavirus: Borna disease virus

Question 6

Bornaviridae exits cells by

Answer 6

budding

Question 7

Bornaviridae in environment

Answer 7

labile

Question 8

Bornaviridae present in

Answer 8

nasal, salivary, and conjunctival secretions

Question 9

Bornaviridae transmission

Answer 9

ingestion or inhalation

Question 10

Bornaviridae affects

Answer 10

mainly horses, also sheep, cattle, foxes, birds, and humans

Question 11

Bornaviridae localisation

Answer 11

grey matter and olfactory bulb

Question 12

Bornaviridae spread

Answer 12

oronasal infection -> CNS through intra-axon spread

Question 13

What happens with Bornaviridae infection

Answer 13

cell-mediated response due to viral ag -> destroyment of neurons

Question 14

diagnosis of borna disease

Answer 14

cns lesions
ag in cerebrospinal fluid
joest-degen bodies (eosinophilic intranucear inclusion)

Question 15

Bornaviridae clinical signs

Answer 15

t-cell mediated severe meningoencephalitis
neurological signs
fever
non-specific signs