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VIROLOGY > Orthomyxoviridae > Flashcards

Orthomyxoviridae Flashcards

1
Q

Surface glycoproteins of Orthomyxoviridae

A

a. Hemagglutinin (HA)
b. Neuraminidase (NA)

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2
Q

rod-shaped spikes which attaches to sialic acid; 16 HA antigens

A

Hemagglutinin (HA)

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3
Q

mushroom-shaped spikes which releases mature virions from infected host cells; 9 NA antigens

A

Neuraminidase (NA)

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4
Q

major genetic changes resulting to novel viral antigens; only Influenza A

A

Antigenic shift

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5
Q

reason why we have pandemic/epidemic

A

Antigenic shift

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6
Q

❖ H1N1:
❖ H2N2:
❖ H3N2:
❖ H5N1:
❖ H7N9:

A

❖ H1N1: Spanish flu
❖ H2N2: Asian flu
❖ H3N2: Hongkong flu
❖ H5N1: Asian Avian flu (Highly pathogenic Avian Influenza)
❖ H7N9: Asian (first reported in China

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7
Q

minor genetic changes that occur infrequently; occurs in all Influenza types

A

Antigen drift

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8
Q

Reason why we have annual vaccination

A

Antigen drift

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9
Q

Paramyxoviridae virus (4)

A

Rubeola/Measles
Rubula/Mump’s
Parainfluenza Virus
Respiratory Syncytial virus

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10
Q

Rubeola/Measles disease (2)

A

➢ Measles – Koplik’s spots in oral mucosa
➢ Subacute sclerosing panencephalitis

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11
Q

Rubula/Mump’s disease (2)

A

➢ Parotitis (swelling of the salivary glands)
➢ Complication: orchitis (inflammation of testicles)

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12
Q

Parainfluenza Virus disease (2)

A

➢ PIV-1: croup(laryngotracheobronchitis)
➢ PIV-3: bronchiolitis & pneumonia

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13
Q

Most significant cause of acute lower respiratory tract infection in children <5 y.o

A

Respiratory Syncytial virus

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14
Q

Picornaviridae viruses (2)

A

Enteroviruses
Rhinovirus

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15
Q

Picornaviridae
acid resistant
acid sensitive

A

Enteroviruses (acid-resistant)
Rhinovirus (acid sensitive)

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16
Q

Enteroviruses (4)

A

Poliovirus,
Coxsackie A
Coxsackie B,
Echovirus

17
Q

Major cause of common cold

A

Rhinovirus

18
Q

Most common cause of aseptic meningitis

A

Enteroviruses

19
Q

Retroviridae virus (3)

A

HIV-1
HIV-2
Human T-Lymphotropic Virus (HTLV-1 & 2)

20
Q

➢ Responsible for the AIDS pandemic
➢ Higher transmission rate

A

HIV-1

21
Q

Most common in West Africa

A

HIV-2

22
Q

Isolated in patients with Hairy Cell Leukemia

A

Human T-Lymphotropic Virus (HTLV-1 & 2)

23
Q

Rhabdoviridae virus

A

Rabies Virus

24
Q

Togaviridae viruses (2)

A

Rubivirus/Rubella
Alphavirus

25
Q

Rubivirus/Rubella disease

A

German measles/ Three-Day Measles – mild exanthematous disease

26
Q

Alphavirus disease (2)

A

➢ Eastern, Western, Venezuelan equine encephalitis
➢ Humans are dead-end hosts

VIROLOGY (8 decks)

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