Ortho + MSK Flashcards

1
Q

Reflexes eponym

A

1,2 buckle my shoe, 3,4 kick the door, 5,6 pick up a stick, 7,8 open the gate

S1 & S2 = Ankle reflex
L3 & L4 = Patellar reflex
C5 & C6 = Biceps reflex
C7 & C8 = Triceps reflex

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2
Q

L3 Radiculopathy

A

Sensory loss to Anterior thigh
Quadricep weakness
Reduced Knee reflex

Test = +ve Femoral stretch test

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3
Q

Which nerve roots does the femoral nerve arise from

A

L2-L4

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4
Q

L4 radiculopathy

A

Sensory loss to anterior Knee
Quad weakness
Reduced knee reflex
+ve femoral stretch test

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5
Q

L5 radiculopathy

A

Anterolateral shin + dosrum of foot sensory loss
Weakness of dorsiflexion (foot drop)
Reflexes intact
+Ve sciatic stretch test

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6
Q

S1 radiculopathy

A

Sensory loss = posterolateral leg
Weakness = Plantarflexion
Reduced ankle reflex
+Ve sciatic stretch test

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7
Q

In which spinal roots does the sciatic nerve originate

A

L4-S3

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8
Q

Cauda equina

A

Surgical emergency where the nerve roots of the cauda equina (L2/L3) are compressed.

Causes = Disc prolapse / Tumor / Spondylethesis / Abscess / Trauma

Features;
* Saddle anaesthesia
* Loss of sensation in bladder + rectum = urinary/fecal incontinence + loss of sphincter tone
* Bilateral sciatica / Bilateral motor weakness in legs
* Sexual dysfunction.

Diagnosis;
* PR - for anal sphincter tone
* Emergency MRI scan

Management = Surgery ASAP

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9
Q

Sciatica

A

Cause = Any compression of the nerve roots of the sciatic nerve (L4-S3) e.g disc herniation / Spinal stenosis / RA / AS / Tumor / Piriformis syndrome / Wallet sciatica / Pregnancy

Sciatic nerve innervates the hamstrings & then splits into the Tibial + Common fibular nerve

Features;
* Sharp shooting pain down posterior leg + back pain
* Unilateral
* Worse on sitting / standing

O/E = +ve sciatic nerve stretch test.

Management = Analgesia + physio. Only MRI if there is signs of UMNL or cauda equina Red Flags.
90% resolve in 6 weeks.

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10
Q

Spondylethesis

A

Displaced vertebral body (typically L5)
Causes - Spondylosis / Degeneration / Malignancy / Trauma / Congenital

Common in younger or much older patients.
Poorly localised back pain which is worse on activity.
Stiffness + waddling gait + Palpable ‘step’ of the spine.

Diagnosis = Xray - shows collaged scotty dog deformity
Management = physio + analgesia + orthotics. May require fusion surgery or decompression.

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11
Q

Spinal stenosis

A

Typically pt >50yrs with sharp lower back pain + tingling down the legs which improves upon rest.
Pain eases when walking up hill and when leaning forward / sitting.

Diagnosis = MRI scan
Management = Physio + Analgesia + Epidural steroids
Weight loss will help
If neurological comprise then laminectomy can be done

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12
Q

How to differentiate between neurogenic claudication and vascular claudication

A

Neurogenic claudication = often alleviated by walking uphill and eased when sitting. pulses intact

Vascular claudication = Worse on walking uphill and pulses may be abnormal.

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13
Q

Schuermanns disease

A

A condition of hyperkyphosis of atleast 3 vertebrae - due to epiphysitis of vertebral joints (cartilage –> bone)

Features;
* Typically presents in adolescence with back pain + stiffnss + progressive kyphosis

Diagnosis = Xray shows epiphyseal plate disturbance + anterior wedging.

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14
Q

Cervical spondylotic myelopathy

A

= Posterior disc protrusion in the cervical spine. Often secondary to spondylosis

Features;
* Neck pain & stiffness
* Slow progression of motor weakness - difficulty walking, spastic paraparesis + reduced hand dexterity.
* May have radiculopathy too
* Autonomic dysfunction can occur e.g incompetence.

Examination findings; +ve hoffman + babinski’s
Invx = MRI
Management = decompression might be needed

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15
Q

Pott’s disease

A

This is TB induced spondylitis due to haematogenous spread.
High risk of disc collapse from caseous necrosis - may cause pott’s paraplegia

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16
Q

What is the most common causative organisms in Discitis

A

Staph aureus - most common
Pseudomonas - in IVDU

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17
Q

What other investigations should be done if Staph aureus discitis is found

A

Echocardiogram - to look for infective endocarditis due to haematogenous spread. (Septic emboli most common cause of discitis / psoas abscess in non IVDU)

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18
Q

Epidural abscess

A

Often forms secondary to discitis

Features;
* Severe localised back pain & tenderness on palpation
* Systemic infection - high fever etc
* Focal neurological deficit possible

Invx = Sepsis screen. MRI is best radiological invx
Consider echo + dental Xray

Management = Long term broad spec antibiotics (IV)

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19
Q

Osteomyelitis

A

Types;
1. Haematogenous - results from a bacteria, more common if immunosupressed / infective endocarditis
2. Non-haematogenous = local spread of infection e.g diabetic foot, PAD - often polymicrobial

Staph aureus most common cause
Salmonella in Sickle cell patients

Invx = MRI
Management = IV antibiotics

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20
Q

Osteopetrosis

A

Marble bone disease - autosomal recessive
Bone becomes harder and more dense
Typically presents in young adults /children

Radiology shows marble bone - lack of differentiation between cortex & medulla

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21
Q

Monteggias fracture

A

Ulnar shaft fracture + Dislocated proximal radioulnar joint

Complication = radial nerve palsy

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22
Q

Galeazzis fracture

A

Radial shaft fracture & Dislocation of the Distal radioulnar joint (DRUJ)

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23
Q

Colles Fracture

A

Distal radius
Dorsally ungulated
Dorsal displacement
Dinner fork deformity

Complications = Median nerve injury + compartment syndrome + EPL rupture + OA.
Mx = Dorsal plaster slab + slight ulnar deviation

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24
Q

Smiths fracture

A

Reverse colles fracture = Volar angulation of distal smiths fracture & garden spade deformity.
Mx = open reduction

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25
Q

Which drug is association with duputryens contracture

A

Phenytoin

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26
Q

NoF fractures

A

Intracapsular/Subcapital - Displaced fractures need athroplasty, undisplaced ones can have Internal fixation or Hemiarthroplasty

Extracapsular - Intertrochanteric can have dynamic hip screw. If displaced or subtrochanteric then intermedullary device is needed.

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27
Q

Salter-Harris Classification

A

I - Straight across growth plate (physis only - Xray may look normal)
II - Above (Physis + metaphysis)
III - Lower or below (physis + epiphysis and includes joint)
IV - Two or through (physis + metaphysis + epihysis)
V - Erasure of growth plate or crush injury (Xray may look normal)

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28
Q

Greenstick fracture

A

Unilateral cortical breech only

29
Q

Buckle / Torus fracture

A

Incomplete cortical distruption resulting in periosteal haematoma only (looks like bilateral swelling on the bone)

30
Q

Barton’s fracture

A

Intra-articular fracture of the distal radius (colles/smiths) with associated radiocarpal dislocation

31
Q

Which is the most common site for a metatarsal stress fracture

A

shaft of 2nd metatarsal

32
Q

Bennets fracture

A

Intra-articular fracture to the base of the thumb
Xray shows a triangular fragment off the base of the thumb
Commonly from fist fights

33
Q

Boxers fracture

A

Fracture to the neck of the 5th metacarpal caused by fist fight usually.

34
Q

Skiers thumb

A

Partial or complete rupture of the Ulnar collateral ligament at the MCPJ joint.
Cause = forced abduction of the thumb
Clinically = tenderness over the UCL. Instability of thumb joint. Can cause a weak pinch grip.

35
Q

Extensor tendon injury

A

Clinically depends on where it is injured - if injured at the wrist then loss of extension at the MCP joint (= drooping of the digit, PIP and DIP compensates)
If injured over the PIP = Boutonniere’s
If injured over the DIP = Mallet finger

36
Q

De Quervains tenosynovitis

A

Inflammation of the tendon sheath containing the APL and EPB at the location of the radial styloid process.
Common in 30-50 year olds.
Associated with RA and pregnancy.

Features;
* Pain over the wrist + Localised tenderness over the anatomical snuffbox + radial styloid process
* Pain worsened by gripping and resisted thumb abduction.

Test = Finkelstein’s test -

37
Q

Side effects of intra-articular steroid injections

A

Pain + swelling (cortisone flare, settles in 1-2days)
Skin discolouration
Hyperglycemia
Infection
Allergic reaction
Subcut skin atrophy
Perihera nerve dysfunction
may lead to cardiac arrythmias if inserted wrong.

38
Q

Axillary nerve palsy

A

Axillary nerve originate from posterior cord of brachial plexus (C5,C6)

Commonly caused by humeral head / anterior shoulder dislocations.

Regimental patch reduced sensation + weakness to teres minor + deltoid. (cannot abduct arm past 15 degrees + loss of contour over shoulder).

39
Q

Radial nerve palsy

A

Radial nerve = posterior cord of brachial plexus (C5-T1)

Common caused by humerus midshaft fracture, drunk arm, handcuffs and monteggia’s fracture

Features;
* Weakness of triceps
* Wrist drop + Weak grip (weakness of finger extension)
* Sensory loss over posterior forearm and dorsolateral hand

40
Q

Musculocutaneous nerve palsy

A

Origin = lateral cord of brachial plexus

Injury is rare as it runs deep in the anteror comparment of arm. Usually results from a brachial plexus injury

Features;
* Weak flexion + supination of arm
* Sensory loss to lateral forearm

41
Q

Median nerve palsy

A

Features depend on where the injury is.
If at wrist level;
* Carpal tunnel syndrome - Thenar wasting & paralysis of opponens pollices (ape hand deformity/hand of benedictin)
* Sensory loss to palmar aspect of lateral 2.5 fingers

If at elbow;
* Same as above +
* Inability to pronate the forearm
* weak flexion of wrist
* ulnar deviation of the wrist

42
Q

Ulnar nerve palsy

A

Originates from medial cord (C8-T1)

Cause of injury = handlebar palsy (cycling) + medial epicondyle fracture + cubital tunnel syndrome.

Features
* Claw hand (if injury to the wrist)
* Intrinsic hand muscle wasting (*except lateral 2 lumbricas - median nerve *) causing weakness in Abduction + Adduction of fingers
* Hypothenar wasting
* Inability to adduct the thumb

O/E = +ve Froment’s sign (difficulty holding paper - they will basically bend their thumb to compensate - flex the FPL)

43
Q

Median nerve motor supply to the hand

A

LOAF
Lateral 2 lumbricals
Opponens pollices
APB
FPB

44
Q

Erb’s palsy

A

= upper brachial plexus injury. (C5/C6)

Common complication of forcep use or shoulder dystocia. Also common in RTAs.

Injuries to the axillary nerve, suprascapular nerve, Musculocutaneous nerve + Long thoracic nerve

Features;
* Adducted extended, internally rotated, pronated arm with flexed wrist (waiters tip)
* Winging of the scapula
* May have diaphragmatic paralysis if phrenic nerve is damaged.

45
Q

Klumpke’s paralysis

A

Lower brachial plexus injury (C8-T1)
Injuries to the radial, ulnar and median nerves

Commonly caused by breech delivery or when grabbing something from a height

Features;
* Paralysis of the intrinsic muscles of the hand
* claw hand
* Horner’s syndrome (if T1 is involved)

46
Q

Carpal tunnel syndrome

A

Compression of the median nerve in the carpal tunnel. More common in females.

Causes = Obesity / Pregnancy / Hypothyroidism / Stress injury / RA / Radial fracture / Oedema / Acromegaly / Lunate fracture

Features;
* Pain or pins and needles in the thumb, index and middle finger. Worse at night. Pt shakes hands to relieve pain.

Signs;
* Weakness of thumb abduction
* Thenar wasting
* Tinel’s sig = tapping causes parasthesia
* Phalen’s = Flexion of the wrist causes symptoms

Management = 6 week conservative treatments (corticosteroid injections + wrist splint at night). If symptoms persist consider surgery.

47
Q

Meralgia paresthetica

A

Entrapment of the lateral femoral cutaneous nerve by the ASIS.
More common in women aged 30-40yrs

RF = Prengnacy / obesity / Surgery / Neuroma / DM / Trauma / Tense ascites

Clinical features;
* Anterolateral thigh pain
* Burning or tingling dysthesia (light touch is painful - allodynia)
* Deep muscle ache in thigh
* Pain worse on standing, relieved by sitting.

O/E - pelvic compression test - compress lateral thigh for 45s with pt lying on side. If painful then +ve test.

Management = LA ultrasound guided injection.

48
Q

Obturator nerve palsy

A

Typically injured from anterior hip dislocation.

Reduced sensation to medial thigh & weakness in Adduction of the thigh.
Clinically = exercise induced medial thigh pain + leg adduction weakness with +ve trendelenburg.

49
Q

Femoral nerve palsy

A

Cause of injury usually hip/pelvic fractures. Femoraly artery/vein catheterisation/ Forceps delivery.

Features;
* Weakness of hip flexion + knee extension
* Loss of patellar reflex
* Sensory changes to anteromedial thigh

50
Q

Sciatic nerve palsy

A

Common injured in hip fracture or surgery
Features;
* Foot drop
* Weak eversion/inversion
* loss of knee flexion
* loss of ankle jerk

51
Q

Main differentiator from common peroneal palsy and sciatic palsy

A

The ankle jerk remains in common peroneal palsy + There will be sensory loss over dorsum of foot.
Whilst both have footdrop

52
Q

Types of peripheral polyneuropathies

A
  1. Axonal - mild-moderate reduction in conduction velocity. Big reduction in amplitude
  2. Demyelinating - significant reduction in velocity but mild reduction in amplitude E.g GBS, Myeloma, Vasculitis.
53
Q

Which polyneuropathies are predominantly motor?

A

CMT
GBS
Diptheria
Lead poisoning
CIDP

54
Q

Which polyneuropathies are predominantly sensory

A

DM
Uremia
Alcoholism
B12
Amyloidosis
Leprosy

55
Q

Diabetic neuropathy

A

Most common metabolic neuropathy. 50% of diabetics get it after 25years.

Features;
* Symmetrical glove + stocking distribution - initially sensiry but can become motor + autonomic as it progresses.
* Acute painful neuropathy
* Gastroparesis - causes bloating + vomitting and may worsen BM.

1st line treatment = amitriptyline, gabapentin, pregabalin or duloxetine

56
Q

Thiamine deficiency

A

= B2

Causes = dietary (dry beri-beri) or Alcoholism

Management = parenteral thiamine

Note = wet beri-beri causes dilated caridomyopathy

57
Q

Charcot marie tooth disease

A

Heriditary sensorimotor neuropathy
Commonly caused by the PMP22 duplication - responsible for the protein in myelin sheaths

Clinical presentation;
* Symmetrical distribution of motor loss - gradual progression over time
* typically occurs in younger adults with an onset of clumsiness, falling, tripping etc
* LMNL signs = *Foot drop + high stepping gait. Weak ankle dorsiflexion, Absent ankle jerk reflex, Leg weakness, Atrophy of calf muscles. *
* Deformities = Claw hammer toes, pes cavus, stork leg deformity.
* Sensory changes - parasthesia, tingling/burning in hands and feed.

58
Q

Guillian barre syndrome

A

Immune mediated demyelination of the peripheral nervous system. Typically triggered by Campylobacter, CMV, or EBV.

Features;
* progressive, ascending symmetrical weakness of limbs starting in legs.
* Reduced/absent reflexes
* Distal parasthesia (glove + stocking distribution)
* Respiratory muscle weakness
* Autonomic involvement = urinary retention, diarrhoea etc
* Cranial nerve involvement = diplopia, bilateral facial nerve palsy, OPA weakness.

Investigations;
* LP = rise in CSF protein but normal WBC
* Nerve conduction sutdies = Inc F wave, Prolonged distal motor latency, Decreased velocity.
* CXR = to rule out sarcoidosis as cause
* Spirometry = to measure disease progression. Respiratory muscle involvement is bad sign. Early intubation needed.

Management;
*Plasma exchange or IV immunoglobulins
Gabapentin / carbamazepine if neuropathic pain

59
Q

Miller-fisher syndrome

A

Sub type of GBS characterised by;
1. ataxia
2. Areflexia
3. Opathalmoplegia
4. Anti-GQB1 antibodies

60
Q

Osteoporosis risk factors

I

A

Increased age
Post menopausal women
Corticosteroid use (equivelant to 7.5mg prednisolone for >3months)
Low BMI
RA
Smoking
Alcohol

61
Q

Which medications can worsen osteoporosis

A

Steroids
PPIs
Heparin
Glitazones
Antiepileptics
SSRIs

62
Q

What is the 1st line treatment in patients with DEXA < -2.5?

A

Alendronate

63
Q

Bisphosphonates

A

MOA = Pyrophosphate analogues. Work by inhibiting osteoclasts therefore preventing bone lysis.

Indications = prevention/treatment of osteoporosis / Pagets disease / Hypercalcemia

SE;
* Osteonecrosis of the jaw
* Atypical stress fractures of the femur proximal shaft
* Hypocalcemia
* Acute phase flu like symptoms
* Oeophageal upset & GI side effects

Contraindications = eGFR < 35

64
Q

Management of osteoporosis

A
  1. Alendronate
  2. Risodronate or Etidronate - 2nd line, only if alendronate can’t be tolerated.
  3. Strontium Ranelate/Raloxifene - 3rd line, have v strict T score criteria i.e may need T < -3.5
  4. Denosumab - strictest criteria. 6 monthly subcut injection.
65
Q

Raloxifene

A

SERM (selective oestrogen receptor modulator)

MOA = Binds to oestrogen receptors activating estrogenic patwhays (inhibits bone remodelling & reabsorption) - particularly useful in the spine (not shown use for non-vertebrae yet)

SE = may worsen menopausal symptoms / Inc risk of VTE / May decrease risk of BC

66
Q

Strontium ranelate

A

moa = Decreases osteoclast differentiation + increases apoptosis. (inhibits bone reabsorption)

Only use in those with no other options.
SE = inc risk of CVD (any existing disease is major contraindication) / inc VTE risk / Steven johnsons syndrome

67
Q

Denosumab

A

moa = human monoclonal antibody that inhibits RANK ligand - inhibiting maturation of osteoclasts.

68
Q

Duration of antibiotic therapy in septic arthritis

A

4-6 weeks