Nephrology Flashcards
NICE diagnostic criteria AKI
- Rise in creatinine >25um/L in 48 hours
- Rise in creatinine >50% from baseline in 7 days
- Urine output <0.5ml/kg/hr for >6 hours
Nephrotoxic drugs
GOD SAD MAN
Gentamicin / Opiates / Diuretics / Sulfonylureas / ACEi & ARBs / DOACs / Metformin / Aldosterone antagonists / NSAIDs
Pre-renal causes of AKI
Pre-renal = hypoperfusion
1. True hypoperfusion = GI losses, dehydration, burns, haemorrhage
2. Relative hypoperfusion = NSAIDs + ACEi
Renal causes of AKI
Glomerulonephritis
Acute tubular necrosis
Acute interstitial nephritis
Vascular causes e.g HUS or malignant HTN
Post-renal causes of AKI
Bilateral pelvic-ureteric obstruction
Bilateral ureteric obstruction
Bladder outflow obstruction
Urethral obstruction
Complications of AKI
Hyperkalemia
Hyperphosphatemia
Uremia
Fluid overload
Metabolic acidosis
Classification of CKD
Stage 1 = Kidney damage + GFR > 90
Stage 2 = Kidney damage + GFR 60-89
Stage 3 = GFR 45 - 59
Stage 3b = GFR 30 - 44
Stage 4 = GFR 15 - 29
Stage 5 (ESRF) = GFR <15
Which medication can cause rhabdomyolysis
Statins
Staging of AKI
Stage 1 = Creatinine rise of >26 in 48hours or 1.5-1.99 x increase from baseline in 7 days
Stage 2 = Creatinine rise of 2 - 2.9 x baseline in 7 days
Stage 3 = Creatinine rise 3x of baseline in 7 days or >350 within 48 hours
Indications for dialysis
“AEIOU”
Acidosis
Electrolyte derangement resistant to treatment
Intoxication
Pulmonary Oedema
Uremia
What should be prescribed to diabetics with a A:CR of >3
ACE inhibitor
Symptoms of uremia
Pruritus
Loss of appetite
Metallic taste in mouth
N&V
Neuropathy
Encephalopathy
Management of CKD
Optimise risk factors - HTN/diabetes etc
Treat any glomerulonephritis
Reduce CVD risk = Atorvostatin 20mg
Reduce complications risk - Low K+ and phosphate diet, maintain healthy weight, stop smoking etc
Complications of CKD
Hypertension
Anemia
Renal bone disease
Hyperkalemia
Management of CKD induced anemia
EPO
Side effects of EPO
Bone aches
Flu like symptoms
Skin rashes
Hypertension
Iron deficiency anemia