Oro-Facial Flashcards
What are the factors affecting taste perception?
Age Meals Hunger Smoking Obesity Pregnancy Cold/Flu/Allergies Disease Temperature Adaptation
What is the main component of umami taste?
L-Glutamate
What is the main component of bitter tastes?
Alkaloids
Sensory pathways for taste in the epiglottis and larynx is innervated by what cranial nerve?
CN X: Vagus
Glossopharyngeal nerve provides taste to what?
Posterior 1/3 of tongue and pharynx
Where do taste signals terminate in the brain?
Gustatory Cortex (Anterior Insulafrontal Operculum)
What are the two measurements for taste acuity?
Detection and Recognition Threshold
T/F Sweet taste is pleasant at low concentrations
False
What is the life span of sustentacular + taste cells?
1-2 weeks
What is the implication of taste for obese people?
Less taste cells > compromised fat sensing system > delays satiety response > excess food intake
What is the difference between ageusia and dysgeusia?
Ageusia: total loss of taste
Dysgeusia: partial loss of taste
Damage to the chorda tympani will result in unilateral or contralateral loss of taste?
Unilateral loss of taste to anterior 2/3rd of the tongue
What can’t the Gates Control Theory explain?
Phantom Pain
T/F: Tonic Receptors are fast adapting
F: Slow Adapting
What are 5 things chemoreceptors can detect?
Taste / Smell / pH (H+) / Plasma O2 / Osmolality
What do Teleceptors detect and give 2 examples
Teleceptors are sensitive to stimuli originating at a distance. Such nerve endings exist in the eyes and ears.
Interoceptors can be found where?
Inside the body, in muscles, tendons and joints such as Muscle Spindles or the TMJ
Where in the Dorsal Column do neurons cross over?
Decusation of Media Leminscus in the medulla oblongata
Where do neurons cross over in the Spinothalamic Tract?
Within the spinal column where the 1st order neuron exists
What sort of sensory input can be found from nerves in the dorsal column?
Fine touch + pressure, vibration, position sensations
What sort of sensory input can be found from nerves in the spinothalamic tract?
Pain, Temperature, Crude Touch/Pressure, Tickle/Itch, Sexual sensations
What is meant by Somatic Sensory Projection?
Body parts represented in the brain is proportional to it’s importance for that species.
Eg: for humans sensory input from fingers + tongue is paramount for speech and fine motor skills
Meissner Corpuscle measure what sensory input?
Dynamic Deformation
Hair Follicles measure what sensory input?
Light Touch
Pacinian Corpuscle measure what sensory input?
Vibration
Merkel Cell measure what sensory input?
Indentation & Depth
Ruffini Corpuscle measure what sensory input?
Stretch
C-Fibre LTM measure what sensory input?
Touch
Mechano-Nociceptor Polymodal Mechano-Nociceptors measure what sensory input?
Injuring Forces
What is meant by Tactile Acuity?
Two points of contact are felt as two distinct points
Can Tactile Acuity cross the midline?
No
What are some examples of Tactile Acuity
Tongue, Finger Tip, Nose
What mucosa in the oral cavity can detect both cold and warm?
Dorsum of Tongue (Strong Both) Ventral Tongue (Moderate Warm/Strong Cold) Labial Mucosa (Moderate Both)
What is the role of Periodontal Mechanoreceptors?
Oral Stereognosis and tactile sensitivity to teeth
What factors affect Oral Stereognosis Ability (OSA)?
- Form, Size and Surface characteristics of the test piece
- Presentation order of the objects
- Age
- Dental Status (poorer with missing dentition, perio, endo treated teeth)
- Duchenne Muscular Dystrophy
Why is Oral Stereognosis important?
For efficient mastication that does not damage hard / soft tissue
Stomatodynia is also known as what?
Burning Mouth Syndrome
What are endogenous mediators of pain for nociceptors?
Bradykinin, H+, Substance P, Histamine, K+
What fibres result in fast pain?
A-Delta Fibres
What is double pain sensation?
A-Delta + C Fibres which conduct the impulses at different velocities
In an inflammatory response what does bradykinin do in terms of pain?
Activates nociceptors
What is Central Sensitisation?
Where the nervous system winds up during a persistent state of high reactivity to pain in order to develop a response to maintain chronic pain. This results in the patient being more sensitive not only to pain but to other sensory input.
What is the role of Substance P during the inflammation of dental pulp?
Vasodilatory Response Histamine Release Increase in blood flow + vascular permeability Increase in blood pressure Synthesis of proinflammatory cytokines Chemotaxis of inflammatory cells Sensitisation of nociceptors
What can modulate pain from ascending pain transmitting tracts?
Endogenous Opiates from Inhibitory interneurons in the dorsal horn
Are A-Beta fibres part of a pain response?
No.
They are large myelinated fibres involved with touch, pressure and proprioception
What are Von Ebner’s Glands and where are they found?
Serous salivary secretion glands found on the lateral surface of Circumvallate Papillae
If a patient is clinically observed with a lack of Filliform Papillae and a bold red appearance, what could this be a sign of?
Low Iron levels in the blood
Where can minor taste organs be found?
Soft + Hard Palate
Pharynx
Larynx
Epiglottis
What is the difference between detection and recongition threshold?
Detection Threshold: the ability to distinguish a taste apart from a drop of water
Recognition Threshold: the concentration needed for a solution to be identified as having a certain taste
Why does xerostomia result in poor taste
Poor saliva results in insufficient solution to transport
What are 3 main reasons for taste disorders?
- Transport Loss (Xerostomia)
- Sensory Loss (Injury to receptor cells)
- Neural Loss ( gustatory afferent nerves + central gustatory pathways)
What are 4 key criteria for the detection of olfactory stimuli?
- Must by volatile - sensitive to changing stimulus
- Sufficiently water soluble
- Must be lipid soluble
- Minimum number of odorous particles must be present for a minimum length of time
What are the 3 phases of the masticatory cycle?
- Opening Phase (Slow > Fast)
- Closing Phase (Fast > Slow)
- Occlusal Phase
What masticatory features would you expect to see in a true carnivore?
- Cylindric TMJ for strong biting hinge movement
- Sharp Teeth
- Fast Muscles
- Dominant Temporalis
What masticatory features would you expect to see in a true herbivore?
- Saucer like TMJ for grinding fibrous food
- Flat Teeth
- Slow Muscles
- Dominant Masseter
What is the role of the Orbicularis Oris in mastication?
To provide an anterior oral seal around the lips
Accessory muscles of mastication Sternohyoid, Sternothyroid, Omohyoid are innervated by what?
C1–C3 Ansa cervicalis
A low innervation ratio for a motor unit is indicative of what?
Low levels of control over a muscle
What 5 types of receptors are responsible for neural control of neural control of the jaw?
- Muscle Spindles
- Tendon Organ Receptors
- TMJ Receptors
- Skin / Mucosal Receptors
- PDL Mechanoreceptors
In which muscles of mastication would we expect to see many muscle spindles?
Temporalis, Masseter, Medial Pterygoid Muscle (Jaw Closers) - stretch of muscles is important in maintaining sense of space
What are the 2 possible actions of an effector in a reflex arc?
- Muscle Contraction
2. Gland Secretion
What would be a trigger for a jaw-opening reflex?
Fishbone wedged in gingiva
What would be a trigger for a jaw-closing reflex?
During running/jumping
Biting on a nut - adjusted less pressure on close
What receptors are responsible for jaw-closing reflexes?
Muscle Spindles in jaw-closer muscles (temporalis, medial pterygoid, masseter)
What receptors are responsible for jaw-opening reflexes?
High-Threshold mechanoreceptors + nociceptors in PDL, gingiva, oral mucosa, tongue, lips, facial skin, nociceptors in tooth pulp
Is Jaw Closing reflex bilateral or unilateral?
Unilateral
T/F Periodontal Reflexes only have reflex inhibition to jaw-closer muscles?
False, they have both
- Reflex inhibition of jaw-closer muscles - on tapping on a tooth, rapid increase in load force (Protective role: eg stone in sandwich)
- Reflex excitation of jaw-closer muscles - o n weak pressure to tooth
(Help guide food into occlusion, coordinate chewing, crushing of food)
With the Peripheral Input + Cortical Input + Central Pattern Generator model for mastication, what is a practical example of when there is a lack of peripheral input?
When a patient is eating whilst under LA - Lack of peripheral feedback generates inefficient and dangerous masticatory strokes possibly leading to soft tissue damage
Where in the brain is swallowing controlled?
The swallowing centre in the pons and medulla oblongata
What are the 4 phases of swallowing?
- Preparatory / Masticatory Phase
- Buccal/Oral Phase
- Pharyngeal Phase
- Oesophageal Phase
What is the Buccal/Oral Phase of swallowing?
Tongue collects food and pushes it back towards the oropharynx
What occurs during the Pharyngeal phase of swallowing?
- Contact of bolus with mechanoreceptors in the pharynx/larynx signals swallowing centre
- Respiration inhibited
- Soft Palate Elevated to seal nasal cavity
- Glottis closes and vocal cords seal entrance to trachea
- Epiglottis tilts backwards to cover glottis
- Larynx is elevated prevent entry of food (involuntary movement)
What occurs during the Oesophageal Phase of swallowing?
- Pharyngo-oesophageal sphincter opens when food/liquid passes
- Glottis re-opens and breathing resumes
- Food then propelled by peristalsis motion down oesophagus
What are the 4 suprahyoid muscles?
The suprahyoid muscles are four muscles located above the hyoid bone in the neck. They are the digastric, stylohyoid, geniohyoid, and mylohyoid muscles
What are the 3 infrahyoid muscles?
Thyrohyoid
Sternohyoid
Omohyoid
What are the 2 main roles of the digastric muscles?
- Assists Lateral Pterygoid in jaw opening
- Regulating the position of the hyoid bone
What does the mylohyoid muscle assist in ?
- Regulating the position of the hyoid bone
- Tongue Movements
Which muscle of mastication is most commonly associated with TMD?
Temporalis
What movements are associated with the Lateral Pterygoid Muscle?
Jaw Opening
Jaw Protrusion
Contralateral Jaw Movements
What are the 2 heads of the Lateral Pterygoid?
Inferior Head of Lateral Pterygoid (IHLP)
Superior Head of Lateral Pterygoid (SHLP)
What are the 2 functions of the Medial Pterygoid Muscle?
Elevates Mandible
Assists Lateral Pterygoid in moving jaw side-to-side
What are the 2 parts of the Masseter Muscle?
Superficial and Deep masseter
T/F Superficial masseter is more active than Deep Masseter
F: Deep Masseter is primarily engaged during mastication + intercuspal open/close excursions
What Muscle Fibre Types are more suitable for postural tasks?
S-Type (Slow Contracting)
What Muscle Fibre Types are more suitable for strong and rapid tasks
F-Types (Fast Contracting)
What type of muscles of mastication are designed to produce velocity and displacement?
Jaw Closers
What type of muscles of mastication are designed to produce force?
Jaw Openers
What is the motion of the temporalis
Elevates and retrudes the mandible at the TMJ
What are the motions of the Inferior Head of Lateral Pterygoid (IHLP)?
Jaw Opening
Jaw Protrusion
Contralateral Jaw Movements
When is the superficial part of the masseter most active?
During Incisal Clenching
T/F: The Superficial Masseter is always more active than the Deep Masseter
False, Deep masseter on both sides is always more
active than superficial masseter
What are the features of S Motor Units?
Slow Contracting
Fatigue-Resistant
What are the features of Fine Motor Units?
Fast Contracting
Intermediate Fatigable
F-Type Motor Units are more suited to what sort of tasks?
Strong and Rapid Bite Tasks
S-Type Motor Units are more suited to what sort of tasks?
Postural Tasks
Which muscle fibres are the best for twitch speed?
FF
Which muscle fibres are the best for twitch strength?
FF
Which muscle fibres are the best for resisting fatigue?
S
Which muscle fibres have the most motoneurons?
FF
Which muscle fibres are activated first?
S
Which muscle fibres have the most powerful contractions?
FF
What is the significance of hybrid Myosin Heavy Chain fibres?
Jaw muscles do a large variety of motor tasks (biting, mastication, swallowing, speech, singing, yawning) &
require a diversity of forces
What are 5 factors affecting the fibre-type composition in jaw muscles
- Age
- Hormones
- Food - hardness
- Adaptation behaviours - dentures, edentulousness
- Craniofacial Morphology (long face, open bite)
What are the 5 steps of initiating muscle contraction?
- ACh released at the neuromuscular junction. Binds to Receptors
- Action potential reaches T Tubules
- Sarcoplasmic reticulum releases Ca2+
- Active site is exposed, Cross-Bridge formation
- Contraction begins
Precise movement is possibly with what sort of motor neuron?
Small Motor Neurons
T/F: Larger Motor Neurons are fatigue resistant
False
What mechanoreceptors are primarily involved during chewing?
Periodontal Mechanoreceptors (PMRs) generate input to 80% of muscle activity for chewinb
What is Fremitus?
Fremitus: a vibration perceptible on palpation; in dentistry, a vibration palpable when the teeth come into contact. This is pathological based on occlusal damage from parafunction or bone resorption
What are causes of muscle plasticity in jaw function?
Tooth extractions
Surgical interventions
Orthodontic interventions
How does Poliomyelitis affect motor units?
Kills motoneurons in Anterior Ventral Spinal Cord
How does Multiple Sclerosis affect motor units?
Demyelination of motor axons
How does Myasthenia Gravis affect motor units?
Blockage of ACh receptors
How does Muscular Dystrophy affect motor units?
Contraction of muscle fibres inhibited
What is an example of reflex inhibition of jaw-closer muscles on a periodontal reflex?
Muscle Inhibition on rapid increase in load force: eg biting down on a stone in a sandwich
What are 2 examples of Jaw Closing/Jerk reflexes?
Maintaining rest position whilst running
Biting on a nut - adjusting for decreased resistance
Dentinal Hypersensitivity is mostly caused by what sort of fluid movement?
Outward: Air, Drilling, Probing, Osmotic Stimuli (Sucrose: draws water out)
What are the 9 components of Neuromatrix pain theory?
Afferent Input Medullary Descending Inhibition Pain Perception Pain Behaviour Psychosocial/Health Status Factors Attention CNS Plasticity Pathologic Input Endocrine, Immune and Autonomic System Activity
T/F: If the Gate is Closed in Gates Control Theory, there is pain
False, if gate is closed there is no pain
In Gates Control Theory, stimulus from small fibres results in what?
Opens the Gate
In Gates Control Theory, stimulus from large fibres results in what?
Closing the Gate: no pain (example: massaging the face during LA to stimulate large fibres)
A lesion within the ventral trigeminothalamic tract after the midline will result in what sort of sensation loss?
Contralateral loss of pain and temperature from the head and face
A lesion within the spinotrigeminal tract will result in what sort of sensation loss?
Ipsilateral loss of pain and temperature from the head and face
What is the tract name for the trigeminal second order axons after they have crossed the midline?
Ventral Trigeminothalamic Tract (Trigeminal Lemniscus)
Trigeminal nerve innervates the orofacial area. What structure is the relay station for the nerve fibres carrying pain sensations from the maxillary molar tooth?
Spinal Nucleus of CN V
Subnucleus Oralis, Interpolaris, Caudalis can be found where?
Within the spinal nucleus of CN V
What can Wide Dynamic Range (WDR) 2nd order neurons respond to?
Respond to noxious/non-noxious stimuli including Light Touch, Temperature, Proprioception
Where do the neurons crossover in the Spinothalamic Tract?
2nd order neuron at the spinal cord associated with the initial sensory input
How can Central Sensitisation be avoided when doing a 3rd molar extraction?
Use of a long acting analgesic and anti-inflammatory post operatively
What 2 things does the release Substance P result in?
- Inflammation Release (mast cell degranulation, histamine, activation of nociceptors)
- Plasma Extravasation
In a hot pulp, what does a oedema result in?
Additional release of bradykinin and activation of nociceptors
What is the role of Calcitonin Gene Related Peptide (CGRP) in a hot pulp?
Results in dilation of peripheral blood vessels and creation of oedema
What 4 things can activate nociceptors during injury?
Damaged Cells: K+
Damaged Vessels: Bradykinin
Damaged Endothelial Cells: Serotonin + Platelets
Mast Cells: Histamine
What 2 chemical can sensitise noiciceptors?
Damaged Cells: Prostaglandins
Primary Afferent: Substance P
What sites of mechanical stimulation can trigger the gag reflex?
Faucial Pillar
Base of the Tongue
Soft Palate
Posterior Pharyngeal Wall
What is the order of relief of pain?
- Relief to burning pain (C Fibres)
- Temperature and Prickling Pain (A-delta Fibres)
- Touch / Pressure sensation (Large A Fibres)
Sensitivity of nerve fibres to LA depends on what 3 things?
- Size of Nerve Fibre: smaller fibres are blocked first
- State of Myelination: myelinated fibres are blocked first
- Rate of Firing: rapidly firing neurons are blocked first as they have more affinity for LA
What fibres are stimulated with FIRST pain?
A Beta - transmits impulses quickly
What sort of fibres are A-Beta Fibres?
Large Myelinated Fibres
Patient feels a throbbing type of poorly localised pain after an injury. What fibres are involved with the pain?
C Fibres
Unmelinated C Fibres are involved with what sort of pain?
Slow Pain
What is Allodynia?
Pain from a stimulus that doesn’t usually invoke pain. eg Trigeminal Neuralgia
What fibres are involved with fast pain?
A-Delta Fibres
What are the characteristics of fast pain?
Sharp Pain
Well Localised
Short Duration
Afferent signals from Thermal + Mechanical Nociceptors