Oral Pathology Flashcards
When does Secondary Syphilis occur?
A mucous patch developing 6-8 weeks after the primary stage
Congenital Syphilis results in what dental abnormalities?
Hypoplastic 1st Molars (Mulberry Molars)
Notched Permanent Incisors (Hutchinson’s Incisors)
What type of bacteria is Syphilis?
Treponema Pallidum (Spirochete)
What sort of necrosis is Gumma (Tertiary Syphilis)?
Coagulation Necrosis
How is Syphilis treated?
Antibiotic treatment with Penicillin
Candidosis is caused by what fungus?
Candida Albicans
What are risk factors that can cause Cancrum Oris (Noma)
Malnutrition, contaminated drinking water, proximity to cattle, lowered immunity (AIDS, Measles)
What are 3 local causes of Oral Candidosis?
Poor Denture Hygiene
Reduced Vertical Dimension
Xerostomia
What are 8 systemic causes of Oral Candidosis?
Extremes of Age Endocrine Disturbances Malnutrition Blood Dycrasias Antibiotic Therapy Advanced Malignancies Postoperative Stress Immunosuppression - Drug induced, HIV, Transplant
Mucocutaneous Oral Candidosis is caused by what?
Usually T-Cell Deficiency
What are the 3 classifications of Oral Candidosis?
Acute, Chronic and Mucocutaneous
Acute Hypertrophic Candidiasis is also known as what?
Thrush
With Acute Hypertrophic Candidiasis, the patient has a white/yellow plaque that can be removed off the mucosa. What is the significance of this plaque?
Plaque is inflammatory exudate - dead cells and fungal colonies
How is a simple thrush case treated?
Use a topical anti-fungal agent and advise patient on good oral hygiene
A Chancre occurs in what stage of Syphilis?
Primary Disease after exposure of T. Pallidum
T/F: Hyperplastic Candidosis is typically associated with red lesions?
False: White patches
What might be one very severe manifestation of Tertiary Syphilis?
Gumma lesion leading to coagulative necrosis and perforation of the palate
T/F: Chancre is the characteristic lesion of Tertiary Syphilis?
False, it is the characteristic painless, ulcerated and localised lesion found in Primary Syphilis
Histologically, what can be seen in a Tertiary Syphilis gumma?
Coagulative necrosis and high numbers of macrophages. It has a similar histologically appearance to TB
How would you test for arrested TB?
Positive skin test
When treating a patient with TB, what would be transmission precautions you would need to take?
- Reappoint where possible
- Negative Pressure Surgery
- Special Ventilation
- Treat patient last in the day
In western countries what demographic are most likely to contract TB?
Immunocompromised - elderly, HIV, patients using Immunosuppressants
How would Gonorrhoea manifest symptoms in the head and neck?
Symptoms non-specific
Infection of pharyngeal mucosa
Pharyngitis, oral ulceration, mucosal erythema
Swollen cervical lymph nodes
What is the radiographic appearance of Chronic Osteomyelitis?
Moth Eaten radiolucency
More commonly affecting the mandible
Areas of Focal Sclerosis
What is the main cause of Acute Atrophic Candidiasis
Poor oral and denture hygiene
What are some possible clinical presentations of Chronic Atrophic Candidiasis?
Non-specific red areas in the mouth Chronic Denture Stomatitis - very clearly follows the location of the denture Median Rhomboid Glossitis Papillary Hyperplasia of the palate Angular Cheilitis
A patient has a form of candidiasis that presents with a mild burning sensation and a non-specific red patch in the mouth. What could this be?
Chronic Atrophic Candidiasis
A patient has a form of candidiasis that presents with a fixed white patch in multiple area. What could this be?
Chronic Hyperplastic Candidiasis
What microorganisms are responsible for ANUG?
Gram Negative Bacteria
What are other risk factors for ANUG?
Stress Smoking Fatigue Poor OH Decreased Host Immune Response
A firm swelling on the submandible region with numerous small yellow granules that suppurate is probably a sign of what infection?
Actinomyces
What bacteria is primarily responsible for acute osteomyelitis?
Staph Aureus
What sort of infection is mot likely to occur in the mouth in Australia: bacterial, fungal or viral?
Fungal
What is the main high risk group for Syphilis in Australia?
Indigenous communities
What are 3 triggers for recurrent herpes simplex
Sunlight
Stress
Immunosuppression
T/F: Shingles can cross the midline based if Herpes Zoster is reactivated from the Trigeminal Ganglion?
False: Herpes Zoster resides within the neural ganglion of CN V so activation will not cross the midline
What are the main risk factors for Shingles?
Being elderly
Immunocompromised
Give 3 examples of localised microdontia
Peg Lateral Incisors
Maxillary 3rd Molars
Supernumerary Teeth
What type of disorder is Ectodermal Dysplasia?
X-Linked Recessive
What are the symptoms of Ectodermal Dysplasia?
- Hypodontia
- Atypical cone-shaped teeth
- Lack of alveolar bone development
- Hypotrichosis: Malformed hair + cutaneous appendages (Nails)
- Anhidrosis (No Sweat Glands)
When might a patient have pseudonodontia?
If they have had teeth extracted
How many teeth need to be missing to qualify as Oligodontia?
6 or more teeth missing from development
What is a Compound Odontome?
A mass of tooth tissue, lots of little teeth inside
What is a Complex Odontome?
A tooth with a complex mixture of enamel, dentine and pulp
How would the tooth count change if a patient was affected by a single instance of dental fusion
1 less tooth - Fusion is the union between dentine/enamel between 2 or more teeth
What is Gemination?
Partial development of two teeth from a single tooth bud following incomplete division. Clinically you would see 2 Crowns sharing same root.
What is the likely cause of concrescence?
Trauma or Overcrowding
How would dilaceration appear clinically?
A traumatised tooth with angulated roots appearing on a radiograph
What is concrescence?
Roots of one or more teeth united by cementum after crown formation
Which teeth are often affected by Dens in Dente?
Maxillary Lateral Incisors
Would a tooth with Taurodontism be more likely to be affected by furcation involvement?
No, due to an elongated crown, the furcation is hence apically displaced
When is pulpitis radiographically viable?
When it has progressed to a periapical granuloma or cyst
Which has more severe pain symptoms: Acute or Chronic irreversible pulpitis?
Acute Irreversible Pulpitis
What sensitivity test will be positive to reversible pulpitis?
Sensitivity to cold
What immune cells are primarily involved with acute irreversible pulpitis?
Mostly neutrophils
What is the likely cause chronic pulpitis?
Inflammation resulting from long-term/low-grade injury
What immune cells are primarily involved with chronic irreversible pulpitis?
Plasma Cells + Lymphocytes. Very few PMNs
Why is pulpal necrosis the likely end point for pulpitis?
- Limited Capacity for drainage: anatomy
- Limited Access for Repair
- Limited space for swelling
- Concentrated Stimulus
- Limitations of Materials to treat
A periapical abscess that drains extra-orally is known as?
A Fistula
A periapical abscess that drains intral-orally is known as?
Sinus Tract
What can be found in the contents of a periapical granuloma formation
- Granulation Tissue
- Fibrous Tissue
- Inflammatory Cells - Macrophages, Lymphocytes, Plasma Cells, PMNs
Where does Herpes Simplex 1 (HSV1) tend to reside?
The Trigeminal Ganglia
Where does Herpes Simplex 2 (HSV2) tend to reside?
The Sacral Ganglia
Is it possible to have HSV2 manifest symptoms in the mouth?
Yes, if HSV-2 is contract through contact with oral sex with an individual with an active outbreak/sore
T/F: You would manage a recurrent bout of
HSV-1 with a topical Acyclovir (Zovirax): antiviral. creme
No, topical are for a sores for recurrent infections. A buccal tablet or oral liquid of Acyclovir can be taken for primary HSV-1 infections
What is the most common viral infection in the mouth?
Core Sores from Herpes Simplex Virus 1
What are the main clinical signs of a primary HSV-1 infection?
- Difficulty eating/drinking
- Vesicular lesions on attached epithelium such as hard palate or dorsum of tongue
- Primary Gingivostomatitis
- Swollen Lymph Glands in the submandibular region
- Fever and Pain
What is the management for a primary HSV-1 infection?
- Analgesics for pain control
- Ensure hydration
- Soft Diet
- Metronidazole Antibiotic Coverage
- Chlorhexidine mouthwash and gel: helps to maintain OH
Acyclovir (Zovirax): antiviral. Taken orally as buccal tablet or oral liquid
What are the clinical symptoms of a secondary HSV-1 infection
Tingling/Buring sensation
Development of blister
Crusting and healing within 10-14 days
How is a secondary HSV-1 lesion treatment
Early topical acyclovir (zovirax) applied in prodromal period may reduce severity of pain
Histologically, what can be seen in a HSV-1 infection?
- Virally infected multinucleated giant cells
- Formation of very shallow intraepithelial vesicles
- Inflammation at site
- Acantholysis: loss of desmosomes resulting in loss of layering of the epithelium. This is what makes the vesicles prone to rupture
Why is varicella-zoster less commonly seen?
Due to effective immunisation program for chicken pox
How is varicella-zoster transmitted?
- Inhalation of droplets
2. Direct Contact
What is the incubation period for varicella-zoster virus?
2 weeks
Where does the Varicella-Zoster Virus remain dormant?
Sensory Ganglion
What are the triggers for Shingles?
Reactivation of Varicella-Zoster Virus due to age / lowered immune function
What is Ramsay-Hunt Syndrome?
Reactivation of Varicella-Zoster Virus in the facial and auditory nerve - leading to hearing loss or facial paralysis
What are treatments to minimise severity of shingles?
Application of topical acyclovir (Zovirax) within 72 hours of the vesciular rash appearing
Presence of a Oral Hairy Leukoplakia from Epstein-Barr virus is a possible indication of what?
Progression of HIV to AIDS
Where is Oral Hairy Leukoplakia most likely found?
Fixed white lesion on the lateral border of the tongue
Who are the most at risk for Epstein-Barr Virus?
HIV
Organ Transplants, Bone Marrow Transplant, Stem Cell Transplant (Immunosuppressed)
How does Kaposi’s sarcoma (Human Herpes 8) present clinically?
Very dark, deep red lesion in sulcus areas
What are 3 main groups affected by Kaposi’s sarcoma
Mediterranean older men
African origin
Immunosuppressed Patients
What are the typical symptoms of Cytomegalovirus (CMV) in a healthy individual?
Flu-like illness that lasts a few days
In which group would you likely see oral manifestations of Cytomegalovirus (CMV)
Oral ulceration in HIV and immunosuppressed individuals
Type 2 and 4 Human Papillomavirus are commonly associated with what?
Veruca Vulgaris (Common Warts)
A slow growing cauliflower-like lesion on the hard/soft palate is a possible sign of what?
Squamous Papilloma (Oral Wart) from Oral HPV infection
Focal Epithelial Hyperplasia is caused by what and where can it be found?
Oral HPV Infection: numerous lesions involving buccal/labial mucosa and the tongue
What is the high risk group for Coxsackie Viruses?
Young children due to poor hygiene and transmission through saliva and faecal-oral spread
How does Hand-Foot-And-Mouth disease manifest orally?
Mild mouth ulceration, difficulty eating and drinking
Where is Herpangina more likely to present orally?
Vesicular lesions that are posteriorly towards the Fauces and Soft Palate
Why would metronidazole be given to a a HSV-1 primary infection?
To prevent secondary bacterial infection
How would Chicken Pox manifest orally?
Oral lesions present as 2-4mm ulcers with erythematous halo (red) with multiple crops developing over 1-2 weeks
Oropharyngeal carcinoma can develop from what viral infection?
HPV Types 16/18
What are the high risk groups of Conduloma Accuminaturm?
Immunocompromised patients (eg HIV)
What immune cell count reduces with the onset of HIV/AIDs?
CD4
What are the 3 main oral manifestations of HIV infections
- Opportunistic Infections
- Atypical presentations of common oral conditions
- Side Effects of Combination therapy for HIV
You see a young male patient with angular cheilitis. Is this normal and what could it be?
It is atypical, could be a marker for HIV infection or immunosupression
Presence of Oral Hairy Leukoplakia is an indicator of what?
Prognostic of viral load for HIV
Where can Oral Hairy Leukoplakia be found?
- Bilaterally on lateral surface of tongue
2. Ventral surface tongue
What are differential diagnosis for Oral Hairy Leukoplakia
- Trauma (most common)
- Lichen Planus
- Neoplasms
What are the atypical presentations of Herpes-Simplex virus in a HIV patient?
I/O presentation rather than general E/O cold sores
What are the atypical presentations of Varicella Zoster Virus in a HIV patient?
Onset of shingles in a young patient
What are the clinical signs of Necrotising Ulcerative Gingivitis in a HIV patient
Similar to ANUG Sudden onset Severely inflamed, ulcerated gingiva Spontaneous bleeding Necrosis - particularly around Interdental papillae Halitosis - is from the necrotic tissue Plaque - poor OH due to pain Pain
What is a good immediate treatment for ANUG?
Irrigate gums with monojet gun with betadine
Who are contraindicated for Betadine irrigation?
People with iodine allergies
What are the high risk groups for Kaposi’s Sarcoma
HIV positive homosexual men - thought to be sexually transmitted
What are treatment options for Kaposi’s Sarcoma?
Radiotherapy
Chemotherapy
Local, intralesional chemotherapy treatment
What might be seen intraorally with AZT treatment for HIV?
Mucosal pigmentation
What group is more pre-disposed to Leukoedema?
Dark skinned populations
What sort of inheritance pattern occurs with White Spongy Naevus?
Autosomal Dominant with variable expression
What are signs and symptoms of Leukoedema?
- Lesion is asymptomatic
- Bilateral expression
- White/Grey translucency
- Thickening of mucosa
- Poorly defined margins
- Lesion disappears when buccal mucosa is stretched
What are signs and symptoms of White Spongy Naevus?
Raised and Flappy White thickening of buccal mucosa
Histologically what is happening with Leukoedema?
- Intracellular Oedema of superficial half of the epithelium
- Large Vacuolated Cells
- Pyknotic (Condensed Chromatin) Nuclei
- Epithelial Hyperplasia
- Broad Elongated Rete Pegs
T/F: Sulcular and Junctional Epithelium normally express rete pegs?
False, in the mouth attached gingival exhibits rete pegs (The infolds of Epithelium into the adjacent CT layers)
What is the aetiology of Leukoedema?
Normal / Developmental. Heightened by local irritation, particularly for smokers
What is the aetiology of White Sponge Naevus?
Genetic inheritance
What is the aetiology of Frictional Keratosis?
Physical Trauma
What is the aetiology of Fordyce Granules?
Developmental
What is the aetiology of Tobacco-Induced Keratosis?
Chemical/Thermal trauma from smoking
What is the aetiology of
Acute Hyperplastic Candidiasis?
Candida Infection
What is the aetiology of
Oral Hairy Leukoplakia?
EBV Infection
What is the aetiology of
Verruciform Xanthoma?
Unknown
What are the common epithelial oral lesions?
Leukoedema Cheek Biting Frictional Keratosis Fordyce Granules Tobacco-Induced Keratosis Acute Hyperplastic Candidiasis
What are some uncommon epithelial oral lesions?
Chemical Burns
White Sponge Nevus
Oral Hairy Leukoplakia
Verruciform Xanthoma
A patient presents with an asymptomatic enlargement of the gingiva, so much so it covers over the teeth.
There is no bleeding or exudate. What could this be?
Gingival Fibromatosis
What are the 2 known types of Gingival Fibromatosis?
- Hereditary
2. Idiopathic
Histologically, what occurs during Gingival Fibromatosis?
- Epithelial Rete Pegs
- Mild chronic inflammatory cell infiltrate
- Growth of avascular dense fibrous CT
What are some differential diagnosis to Gingival Fibromatosis?
- Drug Induced Gingival Hyperplasia
- Neoplastic Disease
- Granulomatous Disease (Foreign Body, Sarcoidosis, Crohn’s)
What are some differential diagnosis to Leukoedema?
Frictional keratosis, tobacco-related keratosis, white sponge nevus