ORLISTAT

Question 1

Orlistat inclusion criteria

Answer 1

• Should only be sold to overweight adults with a BMI >28kg/m2
• Max daily dose of 180mg in divided doses
• Treatment with OTC orlistat should not exceed 6 months

Question 2

MOA

Answer 2

a lipase inhibitor, reduces the absorption of dietary fat.

Question 3

Orlistat Indication

Answer 3

• • mildly hypocaloric diet in
• (BMI) of 30 kg/m2 or more
• BMI of 28 kg/m2 or more in the presence of other risk factors such as type 2 diabetes, hypertension, or hypercholesterolaemia

Question 4

Dose

Answer 4

120 mg up to TDS

Question 5

Administration

Answer 5

immediately before, during, or up to 1 hour after each main meal,

Question 6

Missed dose

Answer 6

if a meal is missed or contains no fat, the dose of orlistat should be omitted

Question 7

When to continue treatment

Answer 7

continue treatment beyond 12 weeks:
- only if weight loss since start of treatment exceeds 5% (target for initial weight loss may be lower in patients with type 2 diabetes),

Question 8

What are the ADRs of orlistat use

Answer 8

Abdominal pain
flatulence
faecal incontinence
fatty stools

Question 9

Orlistat and diet

Answer 9

• May potentially impair the absorption of fat soluble vitamins
• Should be taken in conjunction with low fat, mildly hypocaloric diet

Question 10

What is very rarely associated with orlistat use?→

Answer 10

hepatitis -
abdominal pain
dark urine
jaundice
itching

Question 11

Contraindications

Answer 11

Cholestasis; chronic malabsorption syndrome

Question 12

Breast feeding

Answer 12

Avoid

Question 13

Pregnancy

Answer 13

caution