LIVER DISORDERS Flashcards

1
Q

Cholestasis

A

Impaired bile formation or flow

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2
Q

Cholestasis - symptoms

A

fatigue
pruritus
dark urine
pale
jaundice

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3
Q

Cholestatic pruritus - treatment

A

cholestyramine
ursodeoxycholic acid
rifampicin

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4
Q

Cholestyramine MOA

A
  • anion-exchange resin that is not absorbed from GI tract
  • forms insoluble complex in intestine with bile + other compounds
  • reduction of serum bile = reduction of excess deposition in dermal tissue with resultant decrease in pruritus
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5
Q

Intrahepatic cholestasis - pregnancy

A

During late pregnancy - adverse fetal outcomes
Treatment of pruritus associated - ursodeoxychollic acid

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6
Q

Gallstones

A

Hard mineral or fatty deposit forming stones in the gallbladder bile duct

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7
Q

Gallstones - asymptomatic

A

majority of pts asymptomatic
don’t need to treat

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8
Q

Gallstones - symptoms

A

Irritated/blocked gall bladder
pain
infection
inflammation

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9
Q

Gallstones - if left untreated

A

biliary colic
cholecystitis
cholangitis
pancreatitis

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10
Q

Gallstones - treatment

A

If symptoms develop
surgical removal

Drug treatment
Mild-mod pain: paracetamol/ NSAID

Severe pain: IM diclofenac
Alt: morphine or pethidine

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