Organ Transplant Flashcards

1
Q

criteria for organ transplant

A

presence of end stage disease
failure of conventional therapy
absence of untreatable malignancy or irreversible infection
absence of disease that would attack the transplanted organ

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2
Q

where do organs come from

A

cadaveric donors

living donors

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3
Q

factors considered in decision to allocate an organ

A
ABO blood typing
tissue
size
waiting time
severity of illness
geographic locations
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4
Q

3 gen complications following organ transplant surgery

A

transplant rejection
infection
surgical prblms

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5
Q

3 drug approach to post transplant management

A

induction immunosuppression
maintenance immunosuppressive
anti rejection immunosuppressive

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6
Q

PT considerations for transplant drugs

A

increased risk of infection

serious AEs

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7
Q

hyperacute rejection

A

48 hrs non functional
ABO or human leukocyte antigen blood type
unresponsive to Tx

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8
Q

acute rejection

A

3-12 months
adaptive response involving T cells
verifying ABO and crossmatching decreases likelihood
HLA matching sign improves success rate

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9
Q

chronic rejection

A

most likely antibody mediated - T and B

manifests differently in each organ

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10
Q

S/s of organ transplant infection/rejection

A
●Temperature greater than 38° C (100.5° F)
●Fatigue
●Shaking, chills, body aches
●Sweating
●Diarrhea lasting longer than 2 days
●Dyspnea
●Cough or sore throat
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11
Q

graft vs host disease

A

GvHD is the donors immune cells causing recipient organ rejection

Transplant Rejection is when the recipient immune response rejects the

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12
Q

Actue GvHD vs Chronic

A

acute - cytokine storm

chronic - multiple organ tox

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13
Q

PT considerations for post op transplant

A

extreme weakness - liver
decreased O2 for heart and lung

deconditioned

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14
Q

suitable OM for organ transplant gen

A
mobility
balance
endurance
pain
gait
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15
Q

heart viable

A

4-6hrs

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16
Q

lung viable

A

4-6hrs

17
Q

pancreas viable

A

24hrs

18
Q

liver viable

A

24-30hrs

19
Q

kidney viable

A

48-72hrs

20
Q

pre transplant complications

liver

A

hepatic infection

21
Q

pre transplant complications

kidney

A

dehydration, DM

22
Q

pre transplant complications

prancreas

A

DM

23
Q

intestinal failure pre transplant complications

A

bowel obstructions, Sx of liver failure

24
Q

HF pre transplant complications

A

ischemic and non ischemic causes

25
Q

lungs pre transplant complications

A

infection, COPD exacerbation

26
Q

post op care of transplant recipient

A
muscle weakness
prolonged hospitalization
bedrest
fatigue 
poor breathing mechanics
poor gait
27
Q

GVHD s/s

A

Abdominal pain, N/V/D
Often accompanied by skin rash
Specific to organ