organ donation Flashcards
identifies opportunities to
assess the risks for common post-transplant infections and to develop individualized preventative strategies.
pretransplant evaluation
therapy of choice
for a variety of types of organ failure
solid organs transplantation
two major complications of organ transplantation
infection and malignancy
conditions which may disqualify either
donor or recipient
Hepatitis C virus (HCV) and HIV
two types of serologic
tests for syphilis
non-treponemal
tests and treponemal-specific
tests
detect antibodies against cardiolipin and
are not specific
non-treponemal test
detect antibodies against specific
treponemal antigens
treponemal test
CDC recommends this test which is superior specificity and sensitivity compared with
the fluorescent treponemal
antibody absorption assay.
Treponema pallidum - particle agglutination assay
The two methods to assess
cellular immune response
in vivo tuberculin skin test
(TST) and ex vivo interferon
gamma release assays (IGRA).
elicits a delayed–type
hypersensitivity reaction after
local intradermal application of
purified protein derivative.
tuberculin skin test
diameter of induration after inoculation
greater than or equal to 5
millimeter measure 48-72 hours
greater than or equal to 5
millimeter measure 48-72 hours is considered as
positive result in HIV, recent contacts to
infection TB, and
immunocompromised host
diameter of induration of individuals with any TB risk factors
10-15 mm
Two methods of quantifying GRA
production
enzyme link
immune assay and enzyme link
immunospot assay
if the measure excessed
a specific threshold relative to the
control. Should undergo a
thorough evaluation to rule out
active infection. Treated if there
is no evidence of active TB infection
Positive result
Transplant recipients are _______ are more likely to harbour
TB than the general population
20-74 times
commonly accepted indirect
measure of latent infection
Detecting the cellular response
against TB specific antigen
Transplant recipients are at risk for several parasitic infections including
- toxoplasmosis
- strongyloidiasis
uncommon
but highly morbid infection after
transplantation
toxoplasmosis
toxoplasmosis test involves detection of
IgG antibodies
devastating
disease in transplant recipients,
with 50–70% mortality in those
with hyperinfection syndrome
and disseminated infection.
strongyloidiasis
what is the test for strongyloidiasis
serial stool ova
parasite examinations
ELISA
result from
primary infection reactivation of
latent infection or donor derived
infection
posttransplant
has the
highest sensitivity and involves
inoculating an agar plate with
stool sample and incubating it
for atleast 2 days.
agar plate method
False positive in ELISA
results of cross reactivity
with other helminths infections
Immunologic and virologic control must be
documented prior to transplantation.
HIV
responsible for coordination of the evaluation and preparation of patients for organ transplantation and long-term management of patients after transplant
Transplant Coordinator
Major Responsibilities
Direct Patient Care
Program Development
Research
Education
Consultation
Develop and present information to professional
groups regarding organ transplantation and organ
donation.
education
Participate in the development and implementation
of research protocols and interpret the protocols
for Participation of patient and family members
research
Collaborate in the development of protocols and
guidelines for patient management
Program Development
Develop, implement and evaluate comprehensive
patient education programs
Program Development
Support planning of and participate in clinical
research projects
research
Develop and present information to community
groups regarding organ transplantation and organ
donation
education
Participate in the development of marketing
information regarding organ transplantation and
organ donation.
education
