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Sedative-Hypnotic Drugs > Orexin receptor agonist > Flashcards

Orexin receptor agonist Flashcards

1
Q

What is Orexin?

A

is a second wake-promoting system in the lateral hypothalamus that projects to brainstem and hypothalamic arousal centers

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2
Q

What is the only commercially available Orexin receptor antagonist?

A

Suvorexant (August 2014)

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3
Q

What is the use of Suvorexant (August 2014)?

A

Improves Sleep onset & Reduces Sleep maintenance; t1/2 = 12 h

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4
Q

What is the MOA of Orexin receptor antagonist?

A

Selectively blocks
binding of orexin A and B to
OX1 & OX2 receptors

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5
Q

What is the adverse effects of orexin receptor antagonist?

A

Day-time sleepiness,
sleep paralysis, hallucinations,
suicidal thoughts

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Sedative-Hypnotic Drugs (9 decks)

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