BZDs Pharmcakinetics

Question 1

What are the Short duration BDZs?

Answer 1

Triazolam (t1/2 = 2-6 hr)

Question 2

What are the intermediate BDZs?

Answer 2

Estazolam (t1/2 = 8-24 hr) Temazepam (t1/2 = 8-20 hr) 12-24 hr

Question 3

What are the long BDZs?

Answer 3

Quazepam (t1/2 = 48-120 hr) Flurazepam (t1/2 = 48-120 hr) >24 hr

Question 4

What are the routes of administration of BDZs?

Answer 4

ORAL IM IV

Question 5

What are the pharmokinetic properties of BDZs taken orally?

Answer 5

: All BZ are lipophilic, rapidly and completely absorbed & distributed throughout the body.

Question 6

What are the pharmokinetic properties of BDZs taken IM?

Answer 6

Chlordiazepoxide & diazepam are NOT well absorbed; lorazepam & midazolam are well absorbed.

Question 7

What are the pharmokinetic properties of BDZs taken IV?

Answer 7

Diazepam & Lorazepam used for STATUS EPILEPTICUS

Question 8

What metabolize BDZs?

Answer 8

All BZ are metabolized by the liver to either Active or Inactive metabolites.

Question 9

What are the active metabolite BDZs?

Answer 9

Flurazepam, Quazepam

Question 10

What are the inactive metabolite BDZs?

Answer 10

Triazolam, Estazolm, Temazepam

Question 11

Which BDZs are conjugated with glucoronide to make urinary inactive metabolite and safer for elderly?

Answer 11

Oxazepam, Lorazepam, and Temazepam do not go hepatic metabolism

Question 12

Summary chart for BDZs

Answer 12