Benzodiazepines

Question 1

What are the benzodiazepines?

Answer 1

Estazolam Quazepam Triazolam Flurazepam Temazepam

Question 2

What are the general properties of BZDs?

Answer 2

replaced Barbs for treatment of insomnia & anxiety. suppress slow-wave sleep (SWS; stages 3&4 NREM) & REM sleep and prolong REM latency. Prolong Stage 2 sleep due to ↑ spindle density, ↓ sleep latency, ↑ total sleep time (TST). Acute withdrawal is associated with DECREASED TST as well as REM & SWS rebound.

Question 3

What are The three groups that divides BZDs?

Answer 3

into 3 groups based on t1/2 duration: short-acting ( 24hr).

Question 4

What is the mechanism of BZDs?

Answer 4

allosteric modulators of the GABAA receptor complex by increasing the frequency of the Cl- Channel openings in the presence of GABA and prolongs the miniature inhibitory postsynaptic currents

Question 5

Describe GABAa receptors?

Answer 5

pentameric complex. 7 subunit families 18 subunits in the CNS

Question 6

What is the major subtype combination in the CNS?

Answer 6

alpha1beta2gamma2- 60% of all GABAa receptors in the CNS

Question 7

What is the function alpha 1 GABAa receptor?

Answer 7

Sedation, amnesia, anticonvulsant, ataxia & dependence liability

Question 8

What is the function alpha 2 GABAa receptor?

Answer 8

Anxiolysis, myorelaxation

Question 9

What is the function alpha 3 GABAa receptor?

Answer 9

Anxiolysis, myorelaxation, dopaminergic activity

Question 10

What is the function alpha 5 GABAa receptor?

Answer 10

Memory performance (hippocampus