General Properties of the Sedative-Hypnotic Drugs

Question 1

All sedative-hypnotic drugs can produce what with increasing dose?

Answer 1

Relief of anxiety
Sedation-“Stages of Anesthesia”
Euphoria—Disinhibition
Hypnosis
Anesthesia
Death

all have the ability for abuse and dependence

Question 2

What are the classes of insomnia drugs?

Answer 2

GABA Receptor Agonists (benzodiazepines, non benzodiazapines)
Barbiturates (Obsolete) 
Melatonin Receptor Agonist
Orexin Receptor Antagonists
Histamine Receptor Antagonists
OTCs (Over-The-Counter)

Question 3

What are the current sedative hypnotics?

Answer 3

BENZODIAZEPINES (BDZ)
SELECTIVE BDZ RECEPTOR AGONISTS:
MELATONIN RECEPTOR AGONISTS:
OREXIN RECEPTOR ANTAGONISTS:
HISTAMINE RECEPTOR ANTAGONISTS:

Question 4

What are the benzodidiazepines?

Answer 4

Estazolam Quazepam Triazolam

Flurazepam Temazepam

Question 5

What are the selective benzodiazepines receptor agonists?

Answer 5

Zolpidem (Ambien®)
Zaleplon (Sonata®)
Eszopiclone (Lunesta®)

Question 6

What are the Melatonin receptor agonists?

Answer 6

Ramelteon,

Tasimelteon

Question 7

What are the resin receptor antagonists?

Answer 7

Suvorexant

Question 8

What are the histamine receptor antagonist?

Answer 8

Doxepin