Oral Quick Relief Formulations Flashcards
What are the disadvantages of swallowing oral medications?
Long transit time through GI tract
1st pass effect
Difficulty swallowing
What is their aim?
Accelerate dissolution + absorption
What are the 3 routes?
Sublingual/buccal = oromucosal absorption
Dispersible = GI absorption
Orodispersible = GI absorption
What are the advantages of sublingual/buccal?
Rapid onset for frequent acute episodes
NO swallowing
Avoids drug degradation
NO 1st pass
What are the disadvantages of sublingual/buccal?
Unpleasant taste
Salivary washout
Interferes with eating/drinking
Describe salivary washout
Saliva NOT static
= can be swallowed
= drug into GI tract
What are the advantages of dispersible?
Rapid onset for frequent acute episodes
NO swallowing = taken as a liquid
Oral route well established
Improved bioavailability
What are the disadvantages of dispersible?
Unpleasant taste
Potable (clean) water requirement
What are the advantages of orodispersible?
Rapid onset for frequent acute episodes
NO swallowing
Oral route well established
NO potable water required
Improved bioavailability
What are the disadvantages of orodispersible?
Unpleasant taste
What are the formulation considerations?
Rapid dissolution = superdisintegrant
Taste-masking
Moisture-proof
Describe the oral mucosa structure
Oral epithelium
Basement membrane
Lamina propia
Sub mucosa
Muscle/bone
What is an example of a drug that can be give sublingual/buccal?
Fentanyl
Describe how orodispersible tablets work
Drug released rapidly into saliva
Creates suspension in mouth
Accelerates dissolution
Consider pre-gastric absorption
What are examples of crosslinked polymers?
Crospovidone
Microcrystalline cellulose
