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S3 Case 1 - Neurology > Non-Opioid Drugs > Flashcards

Non-Opioid Drugs Flashcards

1
Q

What do NSAIDS act to relieve?

A

Inflammation

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2
Q

What are the 2 types of NSAIDS?

A

Non-selective COX inhibitors = 1 + 2
Selective COX-2 inhibitors

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3
Q

What is an example of a non-selective NSAID?

A

Ibuprofen

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4
Q

What is an example of a selective COX-2 NSAID?

A

Celecoxib

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5
Q

What do COX enzymes do?

A

Help to convert arachidonic acid to prostaglandins

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6
Q

What are the NSAIDS pharmacological effects?

A

Analgesic (CNS + peripheral)
Antipyretic (CNS)
Anti-inflammatory

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7
Q

What are some adverse effects of NSAIDs?

A

Platelet dysfunction = bleeding
Gastric + peptic ulcers
GI tract bleeding

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8
Q

What is the inhibition of COX-2 due to?

A

Anti-inflammatory actions of NSAIDs

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9
Q

What is the inhibition of COX-1 responsible for?

A

GI tract toxicity

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10
Q

What is an example of a salicylate?

A

Aspirin

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11
Q

What is aspirin’s effect on respiration?

A

High doses = increase CO2 = hyperventilation

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12
Q

What is aspirin’s effect on GI?

A

PGs …
- inhibit stomach acid secretion
- stimulate mucus + HCO3- secretion
= cytoprotective
^^^ THEREFORE NSAIDS STOP THIS ^^^

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13
Q

What is aspirin’s effect on cardiovascular?

A

Inhibition of platelet aggregation
Elevate BP
Destabilise atherosclerotic plaque

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14
Q

What is paracetamol used for?

A

Mild analgesic effect

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15
Q

What are the advantages of paracetamol?

A

Well-absorbed
Without GIT irritation

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16
Q

What are the disadvantages of paracetamol?

A

High doses = severe hepatotoxicity

17
Q

Describe paracetamol’s mechanism of action

A

Centrally + peripherally
Inhibition of PG synthesis in inflamed tissues

18
Q

What are selective COX-2 inhibitors associated with?

A

MI + stroke
= do NOT inhibit platelet aggregation

19
Q

What is an example of an anticonvulsant?

A

Carbamazepine (Na+ blocker)

20
Q

What is an example of an antiepileptic?

A

Gabapentin + pregabalin

21
Q

How does gabapentin + pregabalin work?

A

Act via binding alpha-2,beta-1 subunit of Ca2+ channel

22
Q

What are tricyclic antidepressants (TCA)?

A

Serotonin reuptake inhibitors

23
Q

What is an example of a TCA?

A

Amitriptyline

S3 Case 1 - Neurology (16 decks)

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