Oral Absorption and Other Lipid Drug Delivery Systems (DDS)

Question 1

4 things that affect oral absorption?

Answer 1

1. Solubilization of drug
2. Metabolic degradation (intestinal and liver)
3. Gastric emptying/pH
4. Excipient effects

Question 2

1st strategy to overcome barriers to oral absorption?

Answer 2

1. Tocol emulsion particles >
   - enhance solubility of tocophilic drug
   - protects drug from degradation by GI enzymes
   - protects drug from pH of GIT

Question 3

2nd strategy to overcome barriers to oral absorption?

Answer 3

2. Solid lipid nanoparticles >
   - Drug is incorporated into solid nanoparticle
   - Enhances solubility, protects against pH degradation, protects from GI enzymes

Question 4

3rd strategy to overcome barriers to oral absorption?

Answer 4

3. Polymer lipid micelles

• These micelles are composed of PEG and a phospholipid
• Polymeric chains of PEG cause steric hindrance, preventing enzymes from attaching and breaking down drug