Optic nerve disorders

Question 1

Morning glory disc

Answer 1

• seen with high myopia
• F>M
• Cup filled with glial tissue surrounded by pigment ring
• usually poor VA

Question 2

Optic pit

Answer 2

• inferotemporal most common

- may develop serous RD

Question 3

Melanocytoma

Answer 3

derived from uveal dendritic melanocytes

Question 4

Autosomal dominant optic atrophy

Answer 4

Kjer’s syndrome

• temporal wedge of disc pallor
• OPA1 gene

Question 5

Behr’s syndrome

Answer 5

-diffuse optic atrophy, ataxia, spasticity, MR, hypotonia

Question 6

Wolfram syndrome

Answer 6

AR

• DIDMOAD
• Diabetes insipidus, DM, optic atrophy, deafness

Question 7

LHON

Answer 7

• maternal mitochondrial DNA
• onset btwn 15-30
• vision loss over days
• tobacco or alcohol can trigger decompensation

Question 8

Kearns Sayre syndrome

Answer 8

CPEO with ptosis, pigmentary retinopathy, mild visual loss

• cardiac conduction abnormalities
• ragged red fibers on muscle biopsy