Opioids Flashcards
1
Q
MOA
A
Cellular level - activate receptors.
Relieve dull, deep, visceral pain
2
Q
Receptor locations
A
PAG
Limbic system
Thalamus and hypothalamus
Medulla oblongata
3
Q
Receptor types
A
Mu1 - analgesic, euphoria
Mu2- brain + GIT = respiratory depression and constipation
Kappa - analgesic, sedation
Delta - analgesic
4
Q
Pure agonists
A
Morphine Pethidine Codeine Tramadol Heroine Methadone
5
Q
Partial agonists
A
Pentazocine
Buprenorphine
6
Q
Antagonists
A
Naloxone
Naltrexone
7
Q
Pethidine
A
Analgesic in fetus - cross placenta
Do not constrict pupils, release histamine or suppress a cough
8
Q
Pentazocine
A
Increase pulmonary arterial pressure and is not recommended
9
Q
Side effects of opioids
A
GIT - vomit and nausea
Dependence
10
Q
Side effects of Tramadol
A
Seizures
Psychiatric
Hypotension
11
Q
Naloxone uses
A
Apnoeic infant
Opioid poisoning
