Dyslipidaemias Flashcards
HMG-CoA reductase inhibitor
Statin
6 types of statins
Atorvastatin Lovastatin Simvastatin Rosuvastatin Fluvastatin Pravastatin
Use of Rosuvastatin
Children <8 years
Fluvastatin causes
Hepatic reactions
Simvastatin usage
Hypercholesterolemia
Statin not influenced by food intake and has liver metabolism
Simvastatin
Regulate gene expression and stimulate LpL
Fibrates
Usage of Fibrates
Mixed dyslipidaemias
Types of fibrates
Bezafibrate
Fenofibrate
Gemfibrozil
Contraindication in bezafibrate
Renal and hepatic failure
Fenofibrate may cause
Hemolysis in G6PD deficiency
Gemfibrozil may cause
Leukopenia
Cholestyramine
Ezetimibe
Cholesterol absorption inhibitors
Niacin
Reduce LDL
Increase HDL
Acipimox
Same as niacin - not diabetogenic
Probucol
Policosanol
Omega - 3 - fatty acids
Niacin derivatives