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Pharmacology > Glucocoritcoids and Mineralocorticoids > Flashcards

Glucocoritcoids and Mineralocorticoids Flashcards

1
Q

MOA of Glucocorticoids

A

Inhibit COX - 2 genes to decrease PG synthesis.

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2
Q

Effects of Glucocorticoids

A

Anti-inflammatory
Anti-allergic
Anti-rheumatic
Metabolic effects

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3
Q

Metabolic effects of Glucocorticoids

A

Decrease glucose transport - new onset of diabetes
Increase gluconeogenesis
Increase fatty acid release- deposition in face and trunk
Antigrowth hormone
Adrenal insufficiencies

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4
Q

Glucocorticoid drugs

Mineralocorticoid drugs

A

Hydrocortisone
Dexamethasone
Prednisolone - anti-inflammatory
Betamethasone

Fludrocortisone - adrenocortical insufficiency

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5
Q

MOA of Mineralocorticoids

A

Mimic aldosterone

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6
Q

Conn’s syndrome and treatment

A

Mineralocorticoid excess

Aldosterone antagonists, spironolacetone, eplerenone.

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Pharmacology (4 decks)

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