Opioids

Question 1

Opioid-induced constipation (OIC) can be treat ____ by action as _____

Answer 1

peripherally

mu opioid antagonist (methlnaltrexone)

Question 2

preferred cough suppression because of lower potential for abuse

Answer 2

Dextromethorphan

Question 3

Methadone produces _____

Answer 3

physical dependence + prolong the QT interval (leading to arrhythmias)

Question 4

Meperidine actions on ____ receptors and is used for ____ pain

Answer 4

K

acute

Question 5

Normeperidine is a

Answer 5

neurotoxic metabolite of meperidine

Meperidine = used for moderate to severe pain

Question 6

Buprenorphine is not readily reversed by naloxone

Answer 6

because of the high affinity to opioid receptors = slow dissociation

m= partial agonist 
k = antagonist

Question 7

Pentazocine should not be given to patients with angina or CAD because it

Answer 7

increased BP

a synthetic opioid w/ both agonist & antagonist activity against opiate receptors

Question 8

Tramadol ADR included

Answer 8

overdose with: SSRIs, MAOIs, & tricyclic antidepressants

patients with a history of seizures