Autonomics Drugs

Question 1

A1 receptor pathway
A1 receptor organs
A1 receptor role

Answer 1

A1 receptor pathway: Gq

A1 receptor: Tissue + Glands + Smooth muscles (bladder) + Eyes

A1 receptor: Constriction

Question 2

A2 receptor pathway
A2 receptor organs
A2 receptor role

Answer 2

A2 receptor pathway: Gi
A2 receptor organs: Nerve terminals
A2 receptor role: constriction + decreased NT

Question 3

B1 receptor pathway
B1 receptor organs
B1 receptor role

Answer 3

B1 receptor pathway: Gs
B1 receptor organs: Cardiac + Kidney
B1 receptor role: Constriction

Question 4

B2 receptor pathway
B2 receptor organs
B2 receptor role

Answer 4

B2 receptor pathway: Gs
B2 receptor organs: Smooth muscles + livers + brochodilation
B2 receptor role: relaxation

Question 5

Drugs ending in (-chol) & (-ine)

Answer 5

Direct muscarinic = DUMBBEELSS

Diarrhea 
Urination
Miosis
Bronchoconstriction
Bronchial secretion
Bradycardia 
Emesis 
Excitation
Lacrimation
Salivation 
Sweating

Question 6

Drugs ending in (-stigmine) are

Answer 6

Indirect muscarinic

Inhibits cholinesterase = stops breakdown allowing the Ach to last longer

Question 7

Which drug helps to diagnosis bronchial airway hyper-reactivity?

Answer 7

Methacholine - Direct acting

Question 8

Which drug is used to diagnosis Myasthenia gravis?

Which drug is used to diagnosis types of crisis?

Answer 8

Edrophonium = indirect

Question 9

Which drugs are used to treat Myastenia gravis?

Answer 9

Neostigmine

Pyridostigmine

Question 10

Which drug is used to treat motion sickness?

Answer 10

scopolamine

Question 11

Which drugs cause BOTH mydriasis & cycloplegia (paralysis of the ciliary muscle)

Answer 11

Tropicamide

Cyclopentolate

Question 12

Drugs treat Parkinson’s disease?

Answer 12

Benztropine

Trihexyphenidyl

Question 13

Drugs ending in -azoline

Answer 13

Non-selective alpha agonist

Question 14

Alpha 1 selective agonist

Answer 14

Phenylephrine

Question 15

Drugs ending in -onidine

Answer 15

Alpha 2 selective agonist

Question 16

Methyldopa

Answer 16

is a prodrug that is alpha 2 selective agonist which treats hypertension + withdrawal symptoms

Question 17

Which drugs are non-selective beta agonists (b1 & b2)

Answer 17

Isoproterenol

Epi

Question 18

Drugs ending -terol

Answer 18

Beta 2 agonist

Question 19

Mirabegron is

Answer 19

B3 agonist that tx overactive bladder (increased urinary urgency & frequency) + neurogenic detrusor overactivity

by relaxing bladder muscles

Question 20

Drugs ending in -amine

Answer 20

non-selective alpha blockers

Question 21

Drugs ending in -ozin

Answer 21

Alpha 1 blockers

Question 22

Drugs ending in -olol

Answer 22

Beta blockers

Question 23

Pindolol & Acebutolol are

Answer 23

partial beta agonist meaning that it can help treat asthma & hypertension

Question 24

Reflexes are in response to changes in

Answer 24

blood pressure ONLY

changes in alpha or beta receptors

Question 25

Increases Beta 2 receptors in terms of reflexes

Answer 25

decreased blood pressure causes HR to increase

Question 26

Isoproterenol with an ALPHA blocker leads to

Answer 26

BP is unchanged

Question 27

Isoproterenol with a BETA blocker leads to

Answer 27

BP being normalized

Question 28

Epinephrine with an alpha blocker leads to

Answer 28

Blood pressure will drop because beta is the only receptors being simulated

Question 29

Epinephrine with a beta blocker leads to

Answer 29

Blood pressure would increased because the alpha receptors are being stimulated

Question 30

Norepinephrine with an ALPHA blocker leads to

Answer 30

Blood pressure is normalized

Question 31

Norepinephrine with a BETA blocker leads to

Answer 31

Blood pressure is unchanged

BB stop NE