Autonomics Drugs Flashcards
A1 receptor pathway
A1 receptor organs
A1 receptor role
A1 receptor pathway: Gq
A1 receptor: Tissue + Glands + Smooth muscles (bladder) + Eyes
A1 receptor: Constriction
A2 receptor pathway
A2 receptor organs
A2 receptor role
A2 receptor pathway: Gi
A2 receptor organs: Nerve terminals
A2 receptor role: constriction + decreased NT
B1 receptor pathway
B1 receptor organs
B1 receptor role
B1 receptor pathway: Gs
B1 receptor organs: Cardiac + Kidney
B1 receptor role: Constriction
B2 receptor pathway
B2 receptor organs
B2 receptor role
B2 receptor pathway: Gs
B2 receptor organs: Smooth muscles + livers + brochodilation
B2 receptor role: relaxation
Drugs ending in (-chol) & (-ine)
Direct muscarinic = DUMBBEELSS
Diarrhea Urination Miosis Bronchoconstriction Bronchial secretion Bradycardia Emesis Excitation Lacrimation Salivation Sweating
Drugs ending in (-stigmine) are
Indirect muscarinic
Inhibits cholinesterase = stops breakdown allowing the Ach to last longer
Which drug helps to diagnosis bronchial airway hyper-reactivity?
Methacholine - Direct acting
Which drug is used to diagnosis Myasthenia gravis?
Which drug is used to diagnosis types of crisis?
Edrophonium = indirect
Which drugs are used to treat Myastenia gravis?
Neostigmine
Pyridostigmine
Which drug is used to treat motion sickness?
scopolamine
Which drugs cause BOTH mydriasis & cycloplegia (paralysis of the ciliary muscle)
Tropicamide
Cyclopentolate
Drugs treat Parkinson’s disease?
Benztropine
Trihexyphenidyl
Drugs ending in -azoline
Non-selective alpha agonist
Alpha 1 selective agonist
Phenylephrine
Drugs ending in -onidine
Alpha 2 selective agonist
Methyldopa
is a prodrug that is alpha 2 selective agonist which treats hypertension + withdrawal symptoms
Which drugs are non-selective beta agonists (b1 & b2)
Isoproterenol
Epi
Drugs ending -terol
Beta 2 agonist
Mirabegron is
B3 agonist that tx overactive bladder (increased urinary urgency & frequency) + neurogenic detrusor overactivity
by relaxing bladder muscles
Drugs ending in -amine
non-selective alpha blockers
Drugs ending in -ozin
Alpha 1 blockers
Drugs ending in -olol
Beta blockers
Pindolol & Acebutolol are
partial beta agonist meaning that it can help treat asthma & hypertension
Reflexes are in response to changes in
blood pressure ONLY
changes in alpha or beta receptors
Increases Beta 2 receptors in terms of reflexes
decreased blood pressure causes HR to increase
Isoproterenol with an ALPHA blocker leads to
BP is unchanged
Isoproterenol with a BETA blocker leads to
BP being normalized
Epinephrine with an alpha blocker leads to
Blood pressure will drop because beta is the only receptors being simulated
Epinephrine with a beta blocker leads to
Blood pressure would increased because the alpha receptors are being stimulated
Norepinephrine with an ALPHA blocker leads to
Blood pressure is normalized
Norepinephrine with a BETA blocker leads to
Blood pressure is unchanged
BB stop NE
