Antifungal

Question 1

Polyenes MOA

Answer 1

binding to sterols –> K+ & Mg++ channels forming and being released

Question 2

Both Amphotericin B and Nystatin are in which drug class

Answer 2

Polyenes

Question 3

Azoles MOA

Answer 3

inhibition of 14-a-sterol demethylase

Question 4

Which drug can inhibit excess production of glucocorticoids in pts with Cushing syndrome

Answer 4

Ketocanazole

Question 5

Treats cryptococcal meningitis

Answer 5

Fluconazole because it can penetrate CSF

Question 6

Echinocandins (- fungin) MOA

Answer 6

inhibits formation of 1,3-b-D-glucans in the fungal wall = reduces integrity of the fungal cell wall

(target Fks1p)

Question 7

Griseofulvin MOA

Answer 7

inhibits microtubule function = disrupts assembly of mitotic spindle

Question 8

Griseofulvin treats

Answer 8

fungus containing keratin –> normal tissue

Tinea capitis in children

Question 9

Terbiafine MOA

Answer 9

inhibits fungal squalene epoxidase = blocking erogsterol synthesis
increased sterol squalene = toxic to organism

Question 10

Nystatin is given

Answer 10

topically