Opiods

Question 0

What is the half life of heroin?

Answer 0

30 minutes

Question 1

What is the half life of morphine?

Answer 1

2 hours

Question 2

What is the half life of fentanyl?

Answer 2

3-4 hours

Question 3

What is the morphine equivalent dose of fentanyl?

Answer 3

0.1 IV/IM

Question 4

What is the half life of sufentanil?

Answer 4

2.5-4 hours

Question 5

What is the half life of remifentanil?

Answer 5

9 min

Question 6

What is the morphine equivalent of sufentanil?

Answer 6

.01-.02 IV/IM

Question 7

What is the morphine equivalent of remifentanil?

Answer 7

0.04 IV/IM

Question 8

What is the half life of dilaudid?

Answer 8

2-3 hours (hydromorphone)

Question 9

What is the morphine equivalent of hydromorphone?

Answer 9

1. 3-2 mg IV/IM

7. 5 mg PO

Question 10

What is the morphine equivalent of oxymorphone?

Answer 10

1 mg IV

10 mg PO

Question 11

What is the half life of oxymorphone?

Answer 11

7-9 hours

Question 12

What is the half life of methadone?

Answer 12

15-40 hours

Question 13

What is the half life of hydrocodone?

Answer 13

4 hours

Question 14

What is the half life of oxycodone?

Answer 14

4-5 hours

Question 15

What is the half life of OxyContin?

Answer 15

5-6.5 hours

Question 16

What is the duration of action of naloxone?

Answer 16

30-60 minutes

Question 17

What are the side effects of naloxone?

Answer 17

Opioid withdrawal
HTN
Ventricular dysrhythmia
Pulmonary edema

Question 18

How should naloxone be dosed?

Answer 18

0.5-1 mcg/kg incrementally

Question 19

What are the side effects of opioids?

Answer 19

Cough suppression
Respiratory depression
Constipation
Urinary retention
N/v
Biliary Tract spasm
Histamine release: tachy, flushing, itching, bronchi spasm
Dose dependent brady

Question 20

What is the MOA of methyl naltrexone? What is it used for?

Answer 20

Binds to peripheral opioid receptors
Cannot cross Bb barrier because it is a charged polar molecule

Used for opioid induced constipation

Question 21

What are the cardio effects of opioids?

Answer 21

Brady

Decrease SVR

Question 22

What is meperidine associated with?

Answer 22

Myocardial depression

Seizures

Question 23

What is context sensitive halftime?

Answer 23

The time required for a 50% reduction in the plasma concentration of a drug on termination of a constant infusion.

Depends on elimination and redistribution

Question 24

Why does morphine have a prolonged ventilatory response in patients with renal failure?

Answer 24

Only 5-10% is excreted unchanged by the kidney

The rest is conjugated in the liver and the eliminated by the kidney. The metabolite is 100X more potent at mu receptors

Question 25

What is the onset of fentanyl?

Answer 25

1-3 minutes

Question 26

What is the onset of morphine?

Answer 26

5-15 minutes

Question 27

What is the onset of hydromorphone?

Answer 27

5 minutes

Question 28

When is the peak effect of fentanyl?

Answer 28

3-5 minutes

Question 29

When is the peak effect of morphine?

Answer 29

30-90 minutes

Question 30

When is the peak effect of hydromorphone?

Answer 30

15-30

Question 31

What is the duration of action of IV fentanyl?

Answer 31

0.5-1 hour

Question 32

What is the duration of action of IV morphine?

Answer 32

4-5 hours

Question 33

What is the duration of action of IV hydromorphone?

Answer 33

4-5 hours

Question 34

Which opioids are associated with seizures in patients with renal failure?

Answer 34

Hydromorphone

Meperidine

Question 35

What does remifentanil cause?

Answer 35

Bradycardia
Chest wall rigidity
Hyperalgesia

Question 36

What is unique about remifentanil’s structure?

Answer 36

It has an ester moiety and is metabolized by plasma esterases