opiod- coedine

Question 1

what is codeine used for?

Answer 1

mild to moderate pain when paracetamol is not longer effective
can also be used be anaesthatists post operation for analgesia

Question 2

MOA

Answer 2

codeine and dihydrocodeine work as they are metabolised in the liver into small amounts of morphine and dihydromorphine. agonists of opoid receptors

Question 3

but what can occur in 10% of people?

Answer 3

10% of Caucasians have the cytochrome p450 2d6 variant where codeine has no effect. therefore a synthetic analogue tramadol can be used.

Question 4

SE

Answer 4

nausea constipation drowsiness and dizziness

overdose-neurological and resp depression

Question 5

CI

Answer 5

hepatic and renal impairment lower dose
significant resp disease
lowers seizure threshold should avoid in epileptics->

Question 6

DI

Answer 6

sedating medications such as Tricylic antidepressants,
benzodiazepenes, anti-psychotics

tramadol- TCA, SDRI

Question 7

one thing to be aware of

Answer 7

never give IV

can provide a severe reaction like an anaphylactic like reaction but is not allergic based.