NSAIDS

Question 1

what does it stand for?

Answer 1

non-steroidal anti-inflammatory drugs

Question 2

indication for use

Answer 2

mild to moderate pain as an alternative for paracetamol

pain caused by inflammation such as in gout, arthritis

Question 3

MOA

Answer 3

inhibits prostaglandin synthesis from arachidonic acid

by inhibiting the COX enzyme (cyclooxygenase )

Question 4

whats the difference between cox1 and cox2

Answer 4

cox1 is needed for renal perfusion, preserving integrity of gastric mucosa, inhibiting thrombus formation
cox2 is the inducible form which is present in inflammation and triggers prostaglandin synthesis and causes inflammation andpain

Question 5

name some NSAID include a cox2 specific NSAID

Answer 5

naproxen and ibruprofen

cox2 specific etoricoxib - benefit is that it reducesside effects

Question 6

AE

Answer 6

GI toxicity
renal impairment
hyperensitity reaction -bronchospasm
angioedema and worsen HF and hypertension

Question 7

DI

Answer 7

increased risk of bleeding with warfarin, aspirin and anticoagulants, SSRI

Question 8

CI

Answer 8

renal and hepatic impairment 
known hypersensivitiy 
GI bleeds/PEPTIC ULCER DISEASE 
heart failure
GI ulceration with corticosdeteriods
renal impairment with ACEi and diuretics

Question 9

who should be given what?

Answer 9

PPI

in over 65s, those with comorbidities, those with previous PUD