morphine Flashcards
1
Q
uses
A
treatment and management of acute severe pain
for chronic pain where paracetamol and NSAID are insufficient
relieve breathlessness in end of life care
relieve breathlessness in pulmonary oedema with nitrates, oxygen and furosemide
2
Q
MOA
A
works by activating opiod receptors which activate coupled G protein receptors. this stimulates sympathetic system /fight or flight
reduces oxygen demand and cardiac work
3
Q
SE
A
respiratory depression neurological depression nausea and vomiting as its acts on chemokine receptor constipation itching, sweating and urtcaria dependency and tolerance pupil constriction
4
Q
DI
A
sediating medications such as benzodiazepine, anti-psychotics, tricyclic antidepressants
5
Q
CI
A
Elderly
reduced dose in hepatic and renal impairment
respiratory disease
biliary colic as it causes sphincter of oddi spasm worsening pain
