allopurinol

Question 1

indication of use

Answer 1

prophylaxis of acute gout attack
prophylaxis of uric acid and calcium oxalate renal stones
prevention of hypercaluremia in chemotherapy patients

Question 2

MOA

Answer 2

inhibits enzyme xanthine oxidase to prevent xanthine into uric acid concentration reduces amount available for build up in joint

Question 3

side effects

Answer 3

GI disorder
Withdrawal therapy-if skin rash present, retry but if recurrent rash, stop and discontinue.
hypersensitivity

sometimes can rarely cause seizures, gynaecomastica, fevers, aplastic anaemia

Question 4

DI

Answer 4

amoxicillin and ampicillin increase hypersensivity reaction risk
acei increase hypersensitivity and haematological reaction risk
azathroprine- increase risk for haematological reaction
benzroflumetiozole- increases hypersensivity risk

A and A - haematological

antibiotic, acei and benzofluometrizole- risk for hypersensitivivty

Question 5

things to consider

Answer 5

adequate fluid intake

consider NSAID or colchine for a month (usually 3 months ) post hypercaluremic correction to prevent an acute attack.