Ophthalmology Flashcards

Glaucoma, macular degeneration, cataracts,

1
Q

Presentation of macular degeneration

What is characteristic?

A
  • Progressive reduced vision, blurriness, worse in night time
  • More rapid in ‘wet’ macular degeneration
  • Central scotomas
  • Seeing ‘wavy’ lines
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2
Q

Which type of macular degeneration carries a worse prognosis?

A

Wet macular degeneration

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3
Q

Amsler grid test indication

A

Suspected macular degeneration – metamorphopsia

Detects central visual field defects, metamorphopsia and any dark areas/blind spots (scotomas)

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4
Q

Investigations for macular degeneration

List 4

A
  • Visual acuity test
  • Amsler grid test
  • Slit lamp / fundoscopy to look at retina
  • OCT to look at retinal layers
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5
Q

Fundoscopic findings in dry macular degeneration

A

Drusen (‘d’ for drusen) around the macula.

geeky medics
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6
Q

Fundoscopic findings in wet macular degeneration

A

Subretinal fluid/blood (Leakage)

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7
Q

Management of ‘dry’ atrophic macular degeneration

A

No definitive treatment.

Antioxidants e.g. vit A/C/E and zinc and healthy lifestlye (no smoking.)

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8
Q

Management of ‘wet’ neovascular macular degeneration

A

Anti-VEGF injections (e.g., ranibizumab, aflibercept)

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9
Q

Presentation of cataracts

A
  • Gradual, painless visual loss
  • Loss of colour
  • Halos/glares
  • Reduced/absent red reflex
  • Asymmetrical
  • Often in older adults
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10
Q

Diagnosis of cataracts

A
  • Opacity on slit lamp
  • Snellen chart - reduced visual acuity
  • Possible reduced red reflex
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11
Q

Treatment of cataracts

A

Phacoemulsification + lens replacement surgery

Lens being broken down by US

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12
Q

A patient presents with a sudden, painless loss of vision, what might this be?

A

Occlusion to a cetnral blood vessel supplying the eye:

  • Central retinal artery occlusion
  • Central retinal vein occlusion
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13
Q

How might you differentiate a central retinal artery vs vein occlusion through a fundoscope?

A

Artery: cherry red spot (macula) - blood not going to the eye, white retina

Vein: flame haemorrhages in all quadrants - backlog of blood from blocked vein

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14
Q

What is glaucoma?

A

A group of eye conditions that damage the optic nerve, often due to high intraocular pressure (IOP).

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15
Q

What are the types of glaucoma?

A

Primary open-angle glaucoma (POAG), angle-closure glaucoma, secondary glaucoma, congenital glaucoma.

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16
Q

Most significant risk factor for glaucoma?

A

Raised IOP

Others: Age, FH, ethnicity, myopia,
Acquired: diabetes, hypertension, steroid use.

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17
Q

Pattern of visual loss in primary open-angle glaucoma (POAG)?

Characterise the vision loss.

A

Often asymptomatic in early stages;

If symptomatic: gradual loss of peripheral vision, then progressing centrally. > tunnel vision.

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18
Q

What is the characteristic visual changes in angle-closure glaucoma?

A

Halos around lights.

+ Sudden, severe eye pain, blurred vision with systemic features e.g. headache, N/V.

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19
Q

What is Optical Coherence Tomography (OCT)?

A

Imaging of the optic nerve head and retinal nerve fiber layer.

20
Q

What is gonioscopy?

A

Assessment of the anterior chamber angle.

21
Q

What is the first-line pharmacological treatment for glaucoma/ocular hypertension? (Second-line for glaucoma)

A

Prostaglandin analogues (e.g., latanoprost).

Increases uveoscleral flow.

22
Q

When are beta-blockers used in glaucoma treatment?

A

If prostaglandin analogues are contraindicated or not tolerated.

23
Q

List two types of carbonic anhydrase inhibitors and when they are indicated in glaucoma?

A

Topical (e.g., dorzolamide) or systemic (e.g., acetazolamide).

Acetazolamide is used if high IOP needs to be decreased rapidly, i.e. in acute angle-closure glaucoma where pressure is often very high and vision is threatened.

24
Q

What is a surgical option for open-angle glaucoma if conservative measures fail?

A

Trabeculectomy (creating a new drainage pathway), glaucoma drainage devices.

25
Q

What is the emergency management principles for acute angle-closure glaucoma?

A
  1. Immediate referral to ophthalmology,
  2. medications to lower IOP, and later, possible laser or surgical intervention.
26
Q

Pathophysiology of primary open-angle glaucoma

A

Resistance to outflow at the level of the trabecular meshwork (?stiffening), leading to ↑IOP.

Chronic ↑IOP → damage to the optic nerve head → progressive loss of retinal ganglion cells and optic nerve fibre layer thinning.

Leading to optic nerve damage and visual field loss.

27
Q

Most common type of glaucoma.

A

Primary open-angle glaucoma (POAG)

28
Q

What is considered elavated IOP?

A

> 21 mmHg

29
Q

How is intraocular pressure (IOP) measured?

A

Applanation tonometry

Goldmann-type
30
Q

Automated test to measure visual field defect.

A

Perimetry

Peri- peripheral eyes

31
Q

How is open-angle glaucoma diagnosed?

A
  1. characteristic optic nerve damage (not necessarily with raised IOP)
  2. Visual field defects

IOP may not be raised, but nerve damage may still have occured. This is called ‘Normal-Tension Glaucoma’: treated in basically the same way as POAG

32
Q

Name the condition where raised IOP is the sole presentation.

A

Ocular hypertension.

Increases risk of glaucoma.

33
Q

First-line management of primary open-angle glaucoma/OTN.

How does it work?

A

360° Selective Laser Trabeculoplasty (SLT)

Delays the need for eye drops and a reduced risk of long-term medication use.

SLT helps reduce IOP by improving aqueous outflow through the trabecular meshwork. However, potential side effects include transient discomfort, blurred vision, and photophobia.

A second SLT may be necessary if the initial effect diminishes over time.

34
Q

IOP threshold for treatment (intraocular hypertension and glaucoma).

A

> 24 mmHg

Raised IOP = >21 mmHg

35
Q

Treatment of glaucoma is under …?

A

Ophthalmologists.

36
Q

What are the 2 main pharmacological principles in treating raised IOP?

A
  1. Increased uveoscleral outflow
  2. Reduce aquous production
37
Q

Second-line/adjunctive pharmacological treatment of ocular hypertension/glaucoma (>24mmHg)

If prostaglandin is tried or unsuitable.

A
  • Topical beta-blocker.
  • Switching to, or adding in, topical sympathomimetic (alpha-2-agonsit), a topical carbonic anhydrase inhibitor, a topical miotics or a combination of treatments.
38
Q

What is lataonoprost?

A

A prostaglandin analogue - increases uveroscleral outflow

1st line medication treatment in POAG.

39
Q

How is the angle in the anterior chamber of the eye assessed?

A

Goinoscopy

40
Q

How is the retina visualised and tested?

A
  • Fundoscopy
  • OCT (optical coherence tomography)
41
Q

What is Acute Angle-Closure Glaucoma (AACG)?

A

An ophthalmic emergency characterised by a rapid increase in intraocular pressure (IOP) due to the sudden blockage of the drainage angle in the eye

The elevated pressure can cause optic nerve damage and visual field loss. Factors contributing to angle closure include pupil dilation, lens growth with age, and anatomical predispositions

42
Q

Definitive treatment of acute angle-closure glaucoma.

A

Bilateral laser peripheral iridotomy. (LPI)

Do in both eyes due to unaffected eye is also at high risk

Laser- minimally invasive and quick compared to trabeculectomy.

43
Q

Which beta-blocker is used topically for glaucoma?

A

Timolol

2nd line for open angle glaucoma. Decreases aqueous fluid.

44
Q

Which 2 emergency medication (interim) may be given in a primary setting for acute angle-closure glaucoma?

A
  • pilocarpine eye drops, one drop of 2% in blue eyes or 4% in brown eyes; (miotic, to increase angle)
  • acetazolamide 500 mg orally (systemic carbonic anhydrase inhibitor)

Let the person lie flat with their face up and head not supported by pillows, as this may relieve some of the pressure on the angle.

CKS 2023

Principle of treatment:
- Immediate: decrease IOP to prevent permanent retinal damage.
- Definitive: create flow.

45
Q

A 60 y/o Asian woman complains of a recurrent, unilateral eye pain and blurry vision whenever she enters a dark room/ during night time. It is self-remitting.

What might you be worried about?

A

Chronic angle-closure glaucoma – which can develop into an acute episode.

RFs:
* Increased age (>60)
* Female
* East Asian/inuit descent
* hyperopia (farsightedness)
* family history

46
Q

What is pilocarpine?

A

Miotic - increases angle/uveroscleral outflow

47
Q

What do you expect to find on examination in a patient with acute glaucoma?

List 2 features.

A
  1. Hard and tender red eye,
  2. fixed, semi-dilated pupil.