Facts Flashcards
1
Q
Main indication for mycophenalate (CellCept)
A
Not first-line
Prevent organ transplant rejection (with steroid and ciclosporin)
2
Q
Off-label uses for mycophenalate
A
- Scleroderma - Pulmonary fibrosis
- Lupus nephritis
3
Q
Mechanism of action of mycophenalate
A
- Reduces lymphocyte production
- by inhibiting the IMPDH enzyme
- Essential for guanide nucleotide synthesis
Resulting in immunosuppressive action
4
Q
Management strategy of pulmonary hypertension
A
Endothelin receptor antagonists e.g. bosentan
Endothelin-1 is one of the chemicals that cause vasoconstriction, alongside others e.g. angiotensin II, noradrenaline, ADH
5
Q
Pityriasis versicolor confirmatory test.
A
KOH preparation.
6
Q
Pityriasis versicolor causative organism.
A
Malassezia species (yeast).
