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Strabismus 106 > Ophthalmic Drugs > Flashcards

Ophthalmic Drugs Flashcards

1
Q

Describe the sphincter pupillae muscles

A

Ring of smooth muscle fibres around the pupil that, when contracted constricts the pupil. Part of the parasympathetic system.

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2
Q

The sphincter pupillae muscles are part of which system?

A

Parasympathetic system with ACh as the neurotransmitter

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3
Q

Describe the dilater pupillae muscles

A

Thin layer of myoepithelium that extends from iris root to sphincter pupillae and when contracting allows for the pupil to dilate. Part of the sympathetic system.

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4
Q

The dilater pupillae muscles are part of which system?

A

Part of the sympathetic system. Noradrenaline as the neurotransmitter

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5
Q

What does the PNS do in relation to the eye?

A

Supplies the sphincter pupillae and ciliary muscle and constricts the pupil. It allows for accommodation.

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6
Q

What does the Sympathetic nervous system do in relation to the eye?

A

Supplies the dilator pupillae within the iris and dilates the pupil

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7
Q

What is the neurotransmitter in the PNS?

A

ACH is released from the nerve and binds to ACh receptors on the post-synaptic membrane.
Acetyl cholinesterase (enzyme) terminates the signal.
This is for nerve to nerve or nerve to muscle

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8
Q

What is the neurotransmitter involved in the sympathetic nervous system?

A

Noradrenaline

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9
Q

What is a parasympathomimetic drug?

A

It mimics ACh meaning it causes the action potential to be higher.
As it also is an agonist to the PNS it further increases the action potential

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10
Q

What is a parasympatholytic drug?

A

It’s an anti-muscarinic meaning that it blocks ACh and thus stops the action potential of the parasympathetic innervation (ACh) and thus is an antagonistic

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11
Q

What is a sympathomimetic drug?

A

Mimics noradrenaline in the sympathetic nervous system and so is an agronomic

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12
Q

What is a sympatholytic drug?

A

Blocks noradrenaline

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13
Q

What are the 4 names of ophthalmic drugs called?

A

Cycloplegic drugs, Mydriatic drugs, Miotic drugs and Local Anaesthetics

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14
Q

What are cycloplegic drugs?

A

They’re parasympatholytic meaning that they inhibit ACh and thus cause temporary paralysis of the ciliary muscle, no accommodation occurs (cycloplegia) and causes pupil dilation (mydriasis) because the sphincter muscle is inhibited.

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15
Q

When are cycloplegic drugs used?

A

For refraction in children and in myopia studies and are used to check the fundus

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16
Q

What are the 3 cycloplegic drugs?

A

Cyclopentolate, Atropine and Tropicamide

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17
Q

What is cyclopentolate?

A

It’s a cycloplegic drug that is the gold-standard for cycloplegia. It is faster-acting, non-toxic and doesn’t last long. It cannot be used for children <3mo but for between 3mo-12yo use 1% and then in >12yo use 0.5% quantities

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18
Q

What is atropine?

A

It’s a cycloplegic drug that comes from deadly nightshade. It is used in 1% quantities.

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19
Q

What is tropicamide?

A

It’s a cycloplegic drug that is most often used when wanting to dilate the pupil to check the fundus. it can also be used in refraction where there are allergies to cyclopentolate or atropine. Used in 0.5% or 1% quantities.

20
Q

What are mydriatic drugs?

A

Causes mydriasis which is dilation of the pupil as it is a sympathomimetic which means it enhances the action of Noradrenaline in the sympathetic system and so causes the enhancement of the dilator pupillae.

21
Q

When are mydriatic drugs used?

A

In adults for fundus exams.

22
Q

Why would we use mydriatic drugs instead of cycloplegics?

A

Cycloplegic drugs all are mydriatic drugs (cause dilation of the pupil) but sometimes we want mydriasis without significant cycloplegia

23
Q

What are the mydriatic drug?

A

Phenylephrine. It’s a sympathomimetic and agonist and not to be used in anyone with high blood pressure. it almost always uses 2.5% as the 10% version can impact the cardiovascular system.

24
Q

What would we do if we wanted maximum mydriasis?

A

Use a sympathomimetic and an anti-muscarinic/parasympatholytic

25
What are miotic drugs?
They're parasympathomimetic drugs meaning that they block the parasympathetic system ACh and so leads to miosis. It can cause accommodative spasm and it opens the trabecular meshwork and improves aqueous drainage.
26
What are miotic drugs used in?
Previously used in glaucoma but this is rare now. Some now use as presbyopia correction by utilising the pinhole effect of the constricted pupil
27
What is an example of a miotic drug?
Pilocarpine Hydrochloride
28
What are local anaesthetics used in?
Applanation Tonometry which is the measurement of intraocular pressure, involves a prove onto the cornea OR used in Gonioscopy to view the anterior chamber OR used in the forced duction test
29
How are local anaesthetics used?
May be instilled prior to other drops as they reduce the stinging of cycloplegic drops, increase the effectivity of anti-muscarinic and patients must not rub eyes after as they scratch the corneal as unable to feel corneal sensations
30
How does iris pigmentation affect certain drugs?
It can take longer to dilate the eyes/achieve cycloplegia in individuals with brown irises as the iris can absorb some of the drug molecules opposed to going to the muscle site (Lovasik, 1986). Either the dark pigment cells bind to the drug which reduces drug uptake OR the anterior limiting layer of the iris is formed of chromatophores in darker eyes this is thicker and more compact so may block drug uptake.
31
In a case history what do you need to take before administering an ophthalmic drug?
1) Current and previous general health issues 2) Current medications 3) Allergies 4) Whether they've had drops before and any adverse reactions to this
32
What information do you need to provide a patient if administering them ophthalmic drugs?
1) Effect of drops/ointment 2) Side effects (minor) 3) Adverse reactions & where to go if they occur 4) Provide leaflets if available 5) That if using drops/ointment at home then to stop taking them if side effects occur E.g. mydriatic drugs may be troublesome for a child due to the amount of light.
33
How do we administer drops? Step-by-step
1) Wash hands 2) Gently pull down lower lid 3) If an adult, encourage them to look up 4) Drops into lower central fornix 5) Gently press on the tear duct area (punctual occlusion) as wanting to stop systemic absorption into the tear duct 6) Wipe away excess drops to prevent child getting drops on hands and putting fingers in mouth 7) Wash hands
34
How do we administer ointment (oculentum)? Step-by-step.
1) Wash hands 2) Gently pull down lower lid 3) Squeeze approx. 0.5cm of ointment into lower central fornix 4) Massage lids gently 5) Wipe away excess ointment 6) Don't allow child to rub eye and put fingers in mouth 7) Wash hands
35
Why is ointment good in the night by less so during the day?
Good for long-lasting effects at night but it reduces VA
36
What do we need to write in our notes?
1) Drugs used 2) Dosage 3) If instilled in the clinic we need to ask which eye and what time 4) If instilled at home we need to give clear instructions, let them know which eye(s), when, how frequent and when to stop 5) Report any errors or near misses
37
Parasympathomimetic do what to the dilator, ciliary muscle and sphincter muscle?
Dilator - no effect Ciliary Muscles - Enhances. Ciliary spasm, painful and blurred vision Sphincter - Enhances (miosis)
38
LOOK AT SLIDES
39
Parasympatholytics/Anti-mucolytics do what to the dilator, ciliary muscle and sphincter muscle?
Dilator - no effect Ciliary muscle - Blocks = lens wont change shape as ciliary muscle wont contract and thus results in cycloplegia (removal of accommodation) Sphincter - Blocks = mydriasis (as the dilator isn't affected and so has unopposed actions) and cycloplegia
40
Sympathomimetic's do what to the dilator, ciliary muscle and sphincter muscle?
Dilator - Enhances (mydriasis as the dilator is the strongest over the ciliary and sphincter as it's enhanced) Accommodation isn't affected as it doesn't affect the PNS. Ciliary Muscle & Sphincter - No effect
41
Sympatholytic's do what to do the dilator, ciliary muscle and sphincter muscle?
Dilator - Blocks = miosis as the sphincter muscle is unopposed Ciliary Muscle & Sphincter - No effect
42
Which drug would you use in a 13yo for refraction and fundus media check?
0.5% Cyclopentolate
43
Which drug would you use in a 6mo for refraction and fundus and media check?
1% Cyclopentolate
44
Which drug would you use for a 3yo with very dark eyes for refraction?
Local anaesthetics first and then 20 mins later 1 drop of cyclopentolate, then 20 minutes after do examination OR maybe start 1 drop cyclopentolate, wait 20 minutes and do another drop if it didn't work OR straight to atropine and wait a few hours
45
Which drug would you use for a 43yo for a fundus and media check?
Sympathomimetic - Phenylephrine (be aware of blood pressure history and general health with Pheny)

Strabismus 106 (35 decks)

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