OnlineMedEd: Hematology Oncology - "Microcytic Anemia" Flashcards
The microcytic anemias are _____________ anemias.
production
When you see a low MCV, the next test you should order is ______________.
the iron panel: ferritin, serum Fe, TIBC, and iron saturation
What are the four microcytic anemias?
- Iron-deficiency
- Anemia of chronic disease
- Thalassemia
- Sideroblastic
The body needs to absorb about ______ mg of iron per day to replace the daily needs. The max that can be absorbed is ________.
1-2; 3-4
Ferritin represents the ______________.
store of iron in the body (generally in the marrow)
Review the labs that suggest iron deficiency.
- Low serum Fe
- Low ferritin
- High total iron-binding capacity
Technically, the best test for diagnosing iron-deficiency anemia is bone marrow biopsy, but this is rarely done.
The usual replacement recommendation for iron-deficiency anemia is _____________.
324 mg oral iron TID
Also, use stool softeners to prevent constipation.
Describe the three iron labs that will be seen in anemia of chronic disease.
- Low serum Fe (the body is trying to hide the iron from the bacteria)
- High ferritin (the body is hiding iron in the form of ferritin in the bone marrow)
- Low TIBC (the ferritin is increased)
ACID is usually treated with _____________.
EPO and managing the inflammatory process
Generally, those with ___________ anemia are asymptomatic.
chronic-disease
Thalassemia will present with what iron labs?
- Normal serum Fe
- Normal ferritin
- Normal TIBC
Go through the types of alpha and beta thalassemias.
• Alpha:
- missing 1: asymptomatic
- missing 2: mild anemia
- missing 3: severe anemia; transfusion dependent
- missing 4: hydrops fetalis
• Beta:
- missing 1: mild anemia
- missing 2: severe anemia; transfusion dependent
On hemoglobin electrophoresis, beta thalassemia presents with _______________.
alternate alpha binding complexes: alpha2-gamma2 (HgbF), alpha2-delta2 (HgbA2)
A single unit of RBCs contains _______________ iron.
325 mg –enough for a year! –
True or false: repeated transfusions can cause hemochromatosis.
False
It causes hemosiderosis!