OnlineMedEd: Gynecology - "Endometrial Cancer"

Question 1

__________ is protective against endometrial cancer.

Answer 1

Progesterone (because it stabilizes the endometrium)

Question 2

List the risk factors for endometrial cancer.

Answer 2

All endometrial cancer risk factors relate to excess estrogen exposure:
•Age (more time for estrogen exposure)
• Obesity (more peripheral conversion of androgens to estrone)
•PCOS (anovulation leads to unopposed estrogen)
•Nulliparity
• Early menarche or late menopause (longer time for estrogen exposure)
•HRT
• Tamoxifen

Question 3

What is a BSO?

Answer 3

Bilateral salpingo-oophorectomy

Question 4

Why is TAH + BSO the standard treatment for endometrial cancer?

Answer 4

You need to remove the mass and remove the source of estrogen.

Question 5

If a woman comes in with post-menopausal bleeding, then you need to get ______________.

Answer 5

a D&C or endometrial biopsy

Question 6

What should you do in the case of hyperplasia, adenocarcinoma, or metastasis after an endometrial biopsy?

Answer 6

• Hyperplasia: give high dose progesterone to stabilize the tissue
• Adenocarcinoma: TAH + BSO
• Metastasis: TAH + BSO then chemotherapy and radiation