OnlineMedEd: Gastroenterology - "Viral Hepatitis"

Question 1

Review the following for HAV. 
•Route: 
• Acute: 
• Chronic: 
•Genetics (RNA vs. DNA): 
•Vaccine: 
• Serology:

Answer 1

•Route: fecal-oral 
• Acute: yes
• Chronic: no
•Genetics (RNA vs. DNA): RNA
•Vaccine: yes –killed oral 
• Serology: 
- IgM = currently infected; IgG = immune (exposure or vaccine)

Question 2

Review the following for HBV. 
•Route: 
• Acute: 
• Chronic: 
•Genetics (RNA vs. DNA): 
•Vaccine: 
• Serology:

Answer 2

•Route: sex, IV drugs, vertically
• Acute: yes
• Chronic: yes
•Genetics (RNA vs. DNA): DNA
•Vaccine: yes –killed IM
• Serology:
- HbSAg: currently infected
- HbEAg: infected and infectious
- HbSAg IgM: acute infection, early phase
- HbCAg IgG: acute infection, recovery phase
- HbSAg IgG: recovered immune or vaccinated

Question 3

Review the following for HCV. 
•Route: 
• Acute: 
• Chronic: 
•Genetics (RNA vs. DNA): 
•Vaccine: 
• Serology:

Answer 3

•Route: IV drugs, blood transfusions
• Acute: no
• Chronic: yes
•Genetics (RNA vs. DNA): RNA
•Vaccine: no 
• Serology: 
- Ab + , virus + : chronic infection
- AB - , virus + : acute infection
- Ab + , virus - : treated infection

Question 4

Review the following for HDV. 
•Route: 
• Acute: 
• Chronic: 
•Genetics (RNA vs. DNA): 
•Vaccine: 
• Serology:

Answer 4

• Route: co-infection with HBV
• Acute: yes
• Chronic: yes
• Genetics (RNA vs. DNA): RNA
• Vaccine: no
• Serology: no

Question 5

Review the following for HEV. 
•Route: 
• Acute: 
• Chronic: 
•Genetics (RNA vs. DNA): 
•Vaccine: 
• Serology:

Answer 5

• Route: fecal-oral
• Acute: yes
• Chronic: no
• Genetics (RNA vs. DNA): RNA
• Vaccine: ??
• Serology: ??

Question 6

The old treatment for HCV was ____________. Now we have _____________ which is more effective and doesn’t have the negative profile of the old treatments.

Answer 6

ribavirin and interferon-alpha; sofosbuvir and borceprevir