Ondansetron

Question 1

Ondansetron

Presentation

Answer 1

• 4mg wafer
• 4mg in 2mL vial
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Question 2

Ondansetron

Use

Answer 2

• Moderate to severe nausea
• Active vomiting
• Prophylaxis for eye and spinal injuries

Question 3

Ondansetron

Type

Answer 3

• Anti-nauseant and anti-emetic.

Question 4

Ondansetron

Dose

Answer 4

Adults:
•	Oral wafer (preferred):
o	4mg wafer.
o	Repeat dose after 30 minutes if required.
•	IM or slow IV:
o	4mg in 2ml.
o	Repeat the dose after 30 minutes if required.
Paediatric:
•	Oral wafer (preferred):
Weight	Dose
<15kg	1/2 wafer
15 – 30kg	1 wafer
Over 30kg	As per adult dose
•	IM (single dose only):
Age	Dose
2 - 5 years	1mg in 0.5mL
6 - 9 years	2mg in 1mL
10 - 12 years	3mg in 1.5mL
>12 years or >40kg	4mg in 2mL
.

Question 5

Ondansetron

Actions

Answer 5

• Selective 5-HT3 receptor antagonist blocking serotonin centrally in the chemoreceptor trigger zone and peripherally on Vagus nerve terminals.
• Onset of action up to 30 minutes
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Question 6

Ondansetron

Contraindications

Answer 6

• Paediatrics less than 2 years old

* Hypersensitivity

Question 7

Ondansetron

Adverse effects

Answer 7

.•	Headache
•	Malaise/fatigue
•	Drowsiness
•	Dizziness
•	Rash/allergic reaction

Question 8

Ondansetron

Precautions

Answer 8

• Oral wafer is the preferred method of administration for ALL patients unless actively vomiting.
• Administer IV Ondansetron slowly over 2 minutes (neat or diluted) to prevent blurred vision and dizziness.
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